Heptelidic acid CAS: 74310-84-2
MF: C15H20O5
MW: 280.32

Heptelidic acid (CAS 74310-84-2)

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备用名: Heptelidic acid is also known as Koningic acid.
应用; Heptelidic acid is a potent, selective, and irreversible inhibitor of GAPDH and certain DNA polymerases.
CAS号码: 74310-84-2
分子量: 280.32
分子式: C15H20O5
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

Heptelidic acid is a potent and selective GAPDH (glyceraldehyde 3-phosphate dehydrogenase) inhibitor. Heptelidic acid is suggested to act by binding to the essential Cys149 residue in the catalytic site of GADPH. An apoptosis inducer, Heptelidic acid also displays antibiotic, anticancer, and anitmalarial properties. Heptelidic acid can selectively induce apoptosis in high-glycolytic cancer cells whe the generation of ATP in the glycolytic pathway is inhibited. Heptelidic acid is considered a sesquiterpene lactone.


参考文献

1. Endo, A., Hasumi, K., Sakai, K., et al.Specific inhibition of glyceraldehyde-3-phosphate dehydrogenase by koningic acid (heptelidic acid). J.Antibiot.(Tokyo) 38(7), 920-925 (1985).
2. Sakai, K., Hasumi, K., and Endo, A.Identification of koningic acid (heptelidic acid)-modified site in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase. Biochim.Biophys.Acta. 1077(2), 192-196 (1991).
3. Kumagai, S., Narasaki, R., and Hasumi, K.Glucose-dependent active ATP depletion by koningic acid kills high-glycolytic cells. Biochem.Bioph.Res.Commun. 365(2), 362-368 (2008).
4. Yamaguchi, Y., Manita, D., Takeuchi, T., et al.Novel terpenoids, trichoderonic acids A and B isolated from Trichoderma virens, are selective inhibitors of family X DNA polymerases. Bioscience, Biotechnology, and Biochemistry 74(4), 793-801 (2010).

物理状态 :
Solid
来源于 :
Trichoderma sp.
溶解度 :
Soluble in ethanol, DMSO, methanol, and water.
保存 :
Store at -20° C
仅供科研使用。不可用于诊断或治疗。
Beilstein 注册 :
5091359
SMILES :
CC(C)C2CCC1(CO1)[[email protected]@H]3[[email protected]@H]2C=C(COC3=O)C(=O)O[H]

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PMID: # 32615085  Cell. 641-654.e20.

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