Date published: 2026-10-23

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CD44 抗体 (P1G12): sc-53503

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说明书
  • CD44抗体(P1G12)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 针对human来源的HT-1080纤维肉瘤细胞
  • 推荐用于 human 来源的HCAM WB, IP 和 IF检测
  • 看 CD44 (DF1485): sc-7297,可查看有标记的 CD44 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是CD44 Antibody (P1G12) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与CD44 Antibody (P1G12) 打包提供(请参阅下面的订购信息)。
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    関連項目

    细胞黏附分子(CAMs)是一组密切相关的细胞表面糖蛋白,参与细胞与细胞之间的相互作用,在胚胎发生和发育中发挥重要作用。HCAM又称CD44、LHR、MDU2、MDU3、MIC4、Pgp1、HCELL、MUTCH-I或ECMR-III,是一种由742个氨基酸组成的单通道I型膜蛋白,参与造血、淋巴细胞活化和肿瘤转移。HCAM作为透明质酸(HA)的受体,与骨桥蛋白(OPN)等配体相互作用,介导细胞间和细胞-基质间的相互作用,从而在细胞黏附和细胞迁移中发挥重要作用。HCAM包含一个Link结构域,由于选择性剪接事件,HCAM被表达为多种亚型,其中一些被命名为CD44R, CDw44, CD44S, CD44H(造血)和CD44E(上皮)。虽然大多数HCAM剪接变异体在全身组织中都有表达,但有一种特殊的异构体,即CD44H,在癌组织中高水平表达,这表明CD44H剪接变异体在肿瘤进展中发挥重要作用。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    CD44 抗体 (P1G12) 参考文献:

    1. 癌症中的CD44。  |  Naor, D., et al. 2002. Crit Rev Clin Lab Sci. 39: 527-79. PMID: 12484499
    2. 糖蛋白 GPNMB 可通过 CD44 受体减轻星形胶质细胞的炎症反应。  |  Neal, ML., et al. 2018. J Neuroinflammation. 15: 73. PMID: 29519253
    3. CD44在乳腺癌中的作用。  |  Al-Othman, N., et al. 2020. Breast Dis. 39: 1-13. PMID: 31839599
    4. CD44通过介导铁内吞作用调节表观遗传可塑性。  |  Müller, S., et al. 2020. Nat Chem. 12: 929-938. PMID: 32747755
    5. CD44在病理血管生成中的作用。  |  Chen, L., et al. 2020. FASEB J. 34: 13125-13139. PMID: 32830349
    6. CD44:癌症进展的多功能介质。  |  Hassn Mesrati, M., et al. 2021. Biomolecules. 11: PMID: 34944493
    7. 用于癌症治疗的 CD44 靶向纳米载体。  |  Kesharwani, P., et al. 2021. Front Pharmacol. 12: 800481. PMID: 35431911
    8. 膀胱癌中的CD44。  |  Duex, J. and Theodorescu, D. 2024. Cancers (Basel). 16: PMID: 38539529
    9. 通过靶向 CD44 或表皮生长因子受体对上皮样肉瘤进行光免疫otheranostics。  |  Jin, J., et al. 2024. Transl Oncol. 45: 101966. PMID: 38663219
    10. CD44及其在肿瘤疾病中的意义。  |  Xu, Y., et al. 2024. MedComm (2020). 5: e554. PMID: 38783892

    订购信息

    产品名称产品编号规格价格数量收藏夹

    CD44 抗体 (P1G12)

    sc-53503
    200 µg/ml
    $322.00

    CD44 (P1G12): m-IgG Fc BP-HRP 套装

    sc-536976
    200 µg Ab; 10 µg BP
    $361.00

    CD44 (P1G12): m-IgGκ BP-HRP 套装

    sc-534153
    200 µg Ab; 40 µg BP
    $361.00

    CD44 (P1G12): m-IgG1 BP-HRP 套装

    sc-544936
    200 µg Ab; 20 µg BP
    $361.00

    How much sample do you recommend loading on the gel for Western blot detection using HCAM (P1G12): sc-53503?

    Asked by: DefinitelyNotMatt
    We recommend loading 40–60 µg whole cell lysate, 10–20 µg nuclear extract, 5-10 µg transfected lysate, or 10–20 ng purified protein per lane. A link to our complete Western blotting protocol is provided here for your reference: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
    Answered by: Technical Support
    Date published: 2017-03-01
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    Rated 4 out of 5 by MS from Clean bands in WB in AMLClean bands in WB in AML-193 and HL-60 whole cell lysates under non reducing conditions. -SCBT QC
    Date published: 2013-10-17
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    CD44 抗体 (P1G12) is rated 4.0 out of 5 by 1.
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