Halotyrosine Antibody (BTK-94C): sc-293152

Halotyrosine Antibody (BTK-94C) is a mouse monoclonal IgM kappa antibody that detects Halotyrosine in non-species reactive samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Halotyrosine antibody (BTK-94C) is available as a non-conjugated format, specifically designed to identify bromotyrosine modified proteins, which are significant biomarkers of oxidative stress and immune response. Halotyrosine (BTK-94C) antibody detects halotyrosine residues, resulting from tyrosine halogenation, which indicates immune cell activity, particularly eosinophils that release eosinophil peroxidase to generate hypobromite. This reactive species can modify proteins, leading to bromotyrosine residue formation. Elevated halotyrosine modifications have been observed in asthmatic patients, suggesting a connection between halotyrosine and inflammatory processes, while modification levels decrease in response to anti-inflammatory treatments. Halotyrosine monoclonal antibody (BTK-94C) serves as a valuable tool for researchers studying oxidative stress in various diseases and immune response mechanisms.

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Halotyrosine Antibody (BTK-94C) References:

1. 11,17-dideoxyagelorin A and B, new bromotyrosine derivatives and analogs from the marine sponge Suberea aff. praetensa.  |  Kijjoa, A., et al. 2001. Z Naturforsch C J Biosci. 56: 1116-9. PMID: 11837666
2. Further halotyrosine derivatives from the marine sponge Suberea aff. praetensa.  |  Kijjoa, A., et al. 2002. Z Naturforsch C J Biosci. 57: 732-8. PMID: 12241005
3. Detection of modified tyrosines as an inflammation marker in a photo-aged skin model.  |  Ishitsuka, Y., et al. 2007. Photochem Photobiol. 83: 698-705. PMID: 17576380
4. Identifying peroxidases and their oxidants in the early pathology of cystic fibrosis.  |  Thomson, E., et al. 2010. Free Radic Biol Med. 49: 1354-60. PMID: 20647044
5. Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures.  |  Cao, W., et al. 2011. Amino Acids. 40: 1151-8. PMID: 20839013
6. Benzene metabolite 1,2,4-benzenetriol induces halogenated DNA and tyrosines representing halogenative stress in the HL-60 human myeloid cell line.  |  Nishikawa, T., et al. 2012. Environ Health Perspect. 120: 62-7. PMID: 21859636
7. Halogenated tyrosines from the cuticle of Limulus polyphemus (L.).  |  Welinder, BS. 1972. Biochim Biophys Acta. 279: 491-7. PMID: 5082515
8. The properties of beta-galactosidases (Escherichia coli) with halogenated tyrosines.  |  Ring, M. and Huber, RE. 1993. Biochem Cell Biol. 71: 127-32. PMID: 8398070

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Halotyrosine Antibody (BTK-94C) has 2 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Halotyrosine Antibody (BTK-94C) Specifications

Alternate Product Name: Halotyrosine

Product Clone Name: BTK-94C

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: Halotyrosine

Epitope Species: NSR

Product Reactivity/Detection: bromotyrosine modified proteins

Species Reactivity/Detection: NSR

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Halotyrosine Antibody (BTK-94C): N/A