H2-Db Antibody (28-14-8): sc-52541
- H2-Db Antibody (28-14-8) is a mouse monoclonal IgG2a H2-Db antibody, cited in 1 publications, provided at 100 µg/ml
- raised against C3H.SW splenocytes of mouse origin
- recommended for detection of α3 domain of H2-Db class I MHC antigen of mouse origin by IF and FCM; may cross-react with the α3 domain of H2-Ld and with H2-Dq and H2-Lq; non cross-reactive with H2-Kd or H2-Dd
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for H2-Db Antibody (28-14-8). This work is in progress.
H2-Db Antibody (28-14-8) is a mouse monoclonal IgG2a antibody that detects H2-Db protein of mouse origin by immunofluorescence (IF) and flow cytometry (FCM). H2-Db (28-14-8) antibody is available in both non-conjugated and various conjugated forms, including phycoerythrin (PE) and fluorescein isothiocyanate (FITC). The H2 gene complex encodes major histocompatibility complex (MHC) Class I molecules, which are crucial for the immune response as they present endogenously synthesized peptides to CD8+ T lymphocytes, typically cytotoxic T cells. MHC Class I molecules, including H2-Db, are expressed on nearly all nucleated cells, with expression levels varying by cell type, and play a vital role in the positive and negative selection of CD8+ T cells during thymic development. H2-Db′s ability to interact with natural killer (NK) cells is particularly significant, as H2-Db can either inhibit or activate these cells, thereby influencing the overall immune response. Understanding the function and interactions of H2-Db is essential for research in immunology and therapeutic applications, making anti-H2-Db antibody (28-14-8) a valuable tool for scientists studying T cell activation and immune regulation in mouse models.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
H2-Db Antibody (28-14-8) | sc-52541 | 100 µg/ml | $322.00 | |||
H2-Db Antibody (28-14-8) FITC | sc-52541 FITC | 100 tests in 2 ml | $336.00 | |||
H2-Db Antibody (28-14-8) PE | sc-52541 PE | 100 tests in 2 ml | $349.00 |