GSK 1059615 (CAS 958852-01-2)

外观 :

Powder

物理状态 :

Solid

溶解度 :

Soluble in DMSO (10 mM), DMSO:PBS(pH 7.2) 1:1 (0.5 mg/ml), water (<1 mg/ml), ethanol (<1 mg/ml), and DMF (0.25 mg/ml).

保存 :

Store at 4° C

密度 :

1.44 g/cm³ (Predicted)

折射率 :

n²⁰_D 1.76 (Predicted)

IC50 :

PI3Kα: IC₅₀ = 0.4 nM; PI3Kβ: IC₅₀ = 0.6 nM; PI3Kδ: IC₅₀ = 2 nM; PI3Kγ: IC₅₀ = 5 nM; mTOR: IC₅₀ = 12 nM; Inhibits the phosphorylation of Akt at S473: IC₅₀ = 40 nM (T47D and BT474 cancer cells)

Ki 数据 :

PI3Kα: K_i= 0.42 nM; PI3Kβ: K_i= 0.6 nM; PI3Kγ: K_i= 0.47 nM; PI3Kδ: K_i= 1.7 nM

PubChem CID :

MDL 号码 :

MFCD18074517

SMILES :

C1=CC2=NC=CC(=C2C=C1/C=C\\3/C(=O)NC(=O)S3)C4=CC=NC=C4