GRP1 Antibody (E-8): sc-271740
- GRP1 Antibody (E-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 365-397 at the C-terminus of GRP1 of human origin
- recommended for detection of GRP1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for GRP1 Antibody (E-8) for WB applications. These reagents are now offered in bundles with GRP1 Antibody (E-8) (see ordering information below).
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SEE ALSO...
GRP1 Antibody (E-8) is a mouse monoclonal IgG1 antibody that detects GRP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GRP1, or general receptor for phosphoinositides-1, plays a crucial role in cellular signaling and membrane dynamics due to its unique structure, which includes a pleckstrin homology (PH) domain and a Sec7 domain. The PH domain exhibits a high binding affinity for phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), allowing GRP1 to localize to the plasma membrane where GRP1 can interact with various signaling molecules. The Sec7 domain is essential for catalyzing the guanine nucleotide exchange of ADP-ribosylation factor (ARF) proteins, particularly ARF6, which is vital for regulating membrane trafficking and protein sorting. By facilitating the exchange of GTP and GDP on ARF6, GRP1 influences critical processes such as cell adhesion through interactions with integrins. The ability of GRP1 to act as a potential PtdIns(3,4,5)P3 receptor further underscores GRP1′s importance in cellular signaling pathways, making anti-GRP1 antibody (E-8) an invaluable tool for researchers studying these complex mechanisms.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRP1 Antibody (E-8) | sc-271740 | 200 µg/ml | $322.00 | |||
GRP1 Antibody (E-8): m-IgG Fc BP-HRP Bundle | sc-540260 | 200 µg Ab; 10 µg BP | $361.00 | |||
GRP1 Antibody (E-8): m-IgG1 BP-HRP Bundle | sc-542007 | 200 µg Ab; 20 µg BP | $361.00 | |||
GRP1 (E-8) Neutralizing Peptide | sc-271740 P | 100 µg/0.5 ml | $69.00 |