Geranylgeraniol CAS: 24034-73-9
MF: C20H34O
MW: 290.48
An intermediate in the mevalonate pathway.

Geranylgeraniol (CAS 24034-73-9)

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同义词: Tetraprenol; all trans-3,7,11-15-Tetramethyl-2,6,10,14-hexadecatetraen-1-ol
应用; An intermediate in the mevalonate pathway
CAS号码: 24034-73-9
纯度: ≥95%
分子量: 290.48
分子式: C20H34O
* 参考分析证明 大量特定数据 (包括水 含量).
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Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. This compound has been shown to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro When working with statins, geranylgeraniol can reduce the toxicity without inhibiting the cholesterol-producing effects. Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. It has been found to induce apoptosis in HL-60 cells.


参考文献

1. Aiuchi, T., et al. 1998. J. Biochem. 124: 300-303. PMID: 9685718
2. Fisher, J.E., et al. 1999. Proc. Natl. Acad. Sci. U.S.A. 96: 133-138. PMID: 9874784
3. Montero, M.T., et al. 2004. J. Immunol. 173: 4936-4944. PMID: 15470035
4. Campia, I., et al. 2009. Br. J. Pharmacol. 158: 1777-1786. PMID: 19888963

外观 :
Neat oil
物理状态 :
Liquid
溶解度 :
Soluble in DMSO (>25 mg/ml), ethanol (>25 mg/ml), chloroform, dichloromethane, ethyl acetate, hexane, ether, and acetone.
保存 :
Store at -80° C
折射率 :
n20D 1.49
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
5281365
MDL 号码 :
MFCD00129083
Beilstein 注册 :
1913779
SMILES :
CC(=CCC/C(=C/CC/C(=C/CC/C(=C/CO)/C)/C)/C)C

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引用1 - 1011

PMID: # 29167270  Schumacher, MM. et al. 2018. J. Biol. Chem. 293: 312-323.

PMID: # 28351924  McLean, KJ. et al. 2017. MBio. 8:

PMID: # 28710496  de Wolf, E.|Abdullah, MI.|Jones, SM.|Menezes, K.|Moss, DM.|Drijfhout, FP.|Hart, SR.|Hoskins, C.|Stronach, EA.|Richardson, A.| et al. 2017. Sci Rep. 7: 5410.

PMID: # 27121042  Schumacher, MM. et al. 2016. J. Lipid Res. 57: 1286-99.

PMID: # 24860107  Morris, LL. et al. 2014. J. Biol. Chem. 289: 19053-66.

PMID: # 24573296  Mathews, ES. et al. 2014. J. Neurosci. 34: 3402-12.

PMID: # 15247248  Sever, N. et al. 2004. J Biol Chem. 279: 43136-43147.

PMID: # 9874784  Fisher, JE. et al. 1999. Proc. Natl. Acad. Sci. U.S.A. 96: 133-138.

PMID: # 9157972  Miquel, K. et al. 1997. Cancer Res. 57: 1846-1850.

PMID: # 8617711  Otto, JC. et al. 1996. J. Biol. Chem. 271: 4569-4572.

引用1 - 1011
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