GAP-43 Antibody (7B10): sc-33705
- GAP-43 Antibody (7B10) is a mouse monoclonal IgG2a κ, cited in 22 publications, provided at 200 µg/ml
- raised against full length GAP-43 of rat origin
- Anti-GAP-43 Antibody (7B10) is recommended for detection of axonal membrane protein GAP-43 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-GAP-43 Antibody (7B10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for GAP-43 Antibody (7B10) for WB and IHC(P) applications. These reagents are now offered in bundles with GAP-43 Antibody (7B10) (see ordering information below).
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GAP-43 Antibody (7B10) is a mouse monoclonal IgG2a kappa light chain antibody that detects GAP-43 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). GAP-43 Antibody (7B10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GAP-43, also known as growth-associated protein 43, plays a vital role in neuronal development and regeneration, being predominantly expressed in growth cones during these processes. GAP-43 presence is crucial for axonal outgrowth and synapse formation, which are essential for proper neuronal communication and repair following injury. GAP-43 localization in the axonal membrane underscores GAP-43′s importance in facilitating dynamic changes required for neuronal plasticity and regeneration. Additionally, GAP-43 interacts with specific proteins, such as the neuron-specific Elav/Hu family member HuD, which stabilizes GAP-43 mRNA, thereby enhancing protein levels during neuronal development. Notably, studies have shown that heterozygous GAP-43 knockout mice, which exhibit a 50% reduction in GAP-43 levels, demonstrate significant impairments in memory and sensory perception, highlighting GAP-43′s critical role in cognitive functions and neural signaling.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GAP-43 Antibody (7B10) | sc-33705 | 200 µg/ml | $322.00 | |||
GAP-43 Antibody (7B10): m-IgG Fc BP-HRP Bundle | sc-525546 | 200 µg Ab; 10 µg BP | $361.00 | |||
GAP-43 Antibody (7B10): m-IgG2a BP-HRP Bundle | sc-546309 | 200 µg Ab; 10 µg BP | $361.00 | |||
GAP-43 Antibody (7B10) AC | sc-33705 AC | 500 µg/ml, 25% agarose | $424.00 | |||
GAP-43 Antibody (7B10) HRP | sc-33705 HRP | 200 µg/ml | $322.00 | |||
GAP-43 Antibody (7B10) FITC | sc-33705 FITC | 200 µg/ml | $336.00 | |||
GAP-43 Antibody (7B10) PE | sc-33705 PE | 200 µg/ml | $349.00 | |||
GAP-43 Antibody (7B10) Alexa Fluor® 488 | sc-33705 AF488 | 200 µg/ml | $364.00 | |||
GAP-43 Antibody (7B10) Alexa Fluor® 546 | sc-33705 AF546 | 200 µg/ml | $364.00 | |||
GAP-43 Antibody (7B10) Alexa Fluor® 594 | sc-33705 AF594 | 200 µg/ml | $364.00 | |||
GAP-43 Antibody (7B10) Alexa Fluor® 647 | sc-33705 AF647 | 200 µg/ml | $364.00 | |||
GAP-43 Antibody (7B10) Alexa Fluor® 680 | sc-33705 AF680 | 200 µg/ml | $364.00 | |||
GAP-43 Antibody (7B10) Alexa Fluor® 790 | sc-33705 AF790 | 200 µg/ml | $364.00 |