FXYD2 Antibody (ZW-5): sc-81876

FXYD2 Antibody (ZW-5) is a mouse monoclonal IgG2b kappa light chain antibody that detects FXYD2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-FXYD2 antibody (ZW-5) is available as the non-conjugated format. The human FXYD2 gene, located on chromosome 11q23, encodes the γ subunit of Na/K-ATPase (NKA), which plays a crucial role in maintaining cellular ion homeostasis. FXYD2 protein is essential for regulating sodium and potassium gradients across the plasma membrane, which are vital for various physiological processes, including renal sodium reabsorption, muscle contraction, and neuronal excitability. FXYD2 γ subunit enhances NKA activity by inducing ion channel activity, thereby influencing the overall function of the Na/K-ATPase complex. FXYDs are characterized as single-span membrane proteins that contain a distinctive 35 amino acid signature domain, starting with the sequence PFXYD, which includes 7 invariant and 6 conserved amino acids. Other notable members of the FXYD family include FXYD1 (phospholemman), FXYD3 (mammary tumor protein 8), FXYD4 (CHIF), and FXYD5 (RIC), each contributing to the diverse regulatory mechanisms of ion transport in mammalian cells.

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FXYD2 Antibody (ZW-5) References:

1. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression.  |  Sweadner, KJ. and Rael, E. 2000. Genomics. 68: 41-56. PMID: 10950925
2. CHIF, a member of the FXYD protein family, is a regulator of Na,K-ATPase distinct from the gamma-subunit.  |  Béguin, P., et al. 2001. EMBO J. 20: 3993-4002. PMID: 11483503
3. Phospholemman (FXYD1) associates with Na,K-ATPase and regulates its transport properties.  |  Crambert, G., et al. 2002. Proc Natl Acad Sci U S A. 99: 11476-81. PMID: 12169672
4. Expression and characterization of the FXYD ion transport regulators for NMR structural studies in lipid micelles and lipid bilayers.  |  Crowell, KJ., et al. 2003. Biochim Biophys Acta. 1645: 15-21. PMID: 12535606
5. FXYD proteins: new tissue-specific regulators of the ubiquitous Na,K-ATPase.  |  Crambert, G. and Geering, K. 2003. Sci STKE. 2003: RE1. PMID: 12538882
6. Structure-function relations of interactions between Na,K-ATPase, the gamma subunit, and corticosteroid hormone-induced factor.  |  Lindzen, M., et al. 2003. J Biol Chem. 278: 18738-43. PMID: 12626497
7. FXYD2, a γ subunit of Na⁺, K⁺-ATPase, maintains persistent mechanical allodynia induced by inflammation.  |  Wang, F., et al. 2015. Cell Res. 25: 318-34. PMID: 25633594
8. Fxyd2 regulates Aδ- and C-fiber mechanosensitivity and is required for the maintenance of neuropathic pain.  |  Ventéo, S., et al. 2016. Sci Rep. 6: 36407. PMID: 27805035
9. Renal Mg handling, FXYD2 and the central role of the Na,K-ATPase.  |  Mayan, H., et al. 2018. Physiol Rep. 6: e13843. PMID: 30175537
10. Downregulation of FXYD2 Is Associated with Poor Prognosis and Increased Regulatory T Cell Infiltration in Clear Cell Renal Cell Carcinoma.  |  Zhang, Z., et al. 2022. J Immunol Res. 2022: 4946197. PMID: 36313180
11. FXYD2 antisense oligonucleotide provides an efficient approach for long-lasting relief of chronic peripheral pain.  |  Derre, A., et al. 2023. JCI Insight. 8: PMID: 37154155
12. Microglial SIX2 suppresses lipopolysaccharide (LPS)-induced neuroinflammation by up-regulating FXYD2 expression.  |  Cao, XY., et al. 2024. Brain Res Bull. 212: 110970. PMID: 38688414

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FXYD2 Antibody (ZW-5) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-FXYD2 Antibody (ZW-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FXYD2 Antibody (ZW-5) Specifications

Alternate Product Name: FXYD2

Product Clone Name: ZW-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-65

Epitope Target: FXYD2

Epitope Species: human

Product Reactivity/Detection: FXYD2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for FXYD2 Antibody (ZW-5): N/A