Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US, Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxesShips via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal health products, bulky and/or heavy items
Formin 1 Antibody (H-5) is a high quality monoclonal Formin 1 antibody (also designated FMN1 antibody) suitable for the detection of the Formin 1 protein of mouse, rat and human origin. Formin 1 Antibody (H-5) is available as the non-conjugated anti-Formin 1 antibody. The temporal genetic hierarchy influencing normal limb development can deregulate and mediate mammalian developmental syndromes. In mice, the limb deformity (ld) locus influences normal limb development and gives rise to alternative mRNAs that can translate into a family of proteins known as formins. Formins play a crucial role in cytoskeletal reorganization by influencing Actin filament assembly. Formins co-localize with the actin cytoskeleton and can translocate into the cell cytosol and into the nucleus in an HGF-dependent manner. Vertebrate nuclear formins can control polarizing activity in limb buds through establishment of a Sonic hedgehog/FGF-4 feedback loop. Deficiency mutations at the mammalian ld locus lead to profound developmental defects in limb and kidney formation. The human Formin 1 and 2 genes map to chromosome 15q13.3 and 1q43, respectively.
种属 | 基因名称 | 基因ID | 染色质位置 | 亚型(mRNA)即位号码 | 蛋白质即位号码 | OMIM™ 号码 |
---|---|---|---|---|---|---|
Human | FMN1 | 342184 | 15q13.3 | XM_011521504, XM_011521505, XM_011521506, XM_011521507, XM_011521509, XM_011521511, XM_017022130, XM_017022131, XM_017022132, XM_017022133, XM_017022134, XM_017022135, NM_001103184, NM_001277313, NM_001277314, NM_198500 | Q68DA7 | |
Mouse | Fmn1 | 14260 | 2 E4 | XM_006498750, XM_011239294, XM_011239295, XM_011239298, XM_017315533, NM_001043322, NM_001285458, NM_001285459, NM_001287817, NM_001287818, NM_010230 | Q05860 | N/A |