FMR1 Antibody (6A15): sc-57005
- FMR1 Antibody (6A15) is a mouse monoclonal IgG1 provided at 200 µg/ml
- raised against amino-terminal 580 amino acids of His-FMR1 fusion protein of Drosophila melanogaster origin
- recommended for detection of FMR1 of d origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for FMR1 Antibody (6A15). This work is in progress.
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SEE ALSO...
FMR1 Antibody (6A15) is a mouse monoclonal IgG1 antibody that detects FMR1 of Drosophila origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-FMR1 antibody (6A15) is available as the non-conjugated form. The FMR1 gene is crucial for normal cognitive development, as FMR1 encodes the fragile X mental retardation protein (FMRP), an RNA-binding protein that plays a significant role in the regulation of synaptic plasticity and neuronal function. FMRP is essential for the transport and translation of specific mRNAs at synapses, which is vital for learning and memory processes. In fragile X syndrome, the FMR1 gene undergoes transcriptional silencing due to the expansion of a CGG repeat in its 5′ untranslated region, leading to a deficiency of FMRP. This deficiency disrupts the normal regulation of mRNA translation, contributing to the cognitive impairments associated with the syndrome. FMR1 is localized in both the nucleus and the cytoplasm, and FMR1′s ability to interact with other proteins, such as FXR1 and FXR2, further underscores its importance in mRNA transport and regulation. The presence of both a nuclear localization signal and a nuclear export signal in FMRP highlights FMRP′s dual role in nucleocytoplasmic transport, making FMRP a key player in the cellular mechanisms underlying fragile X syndrome and related disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FMR1 Antibody (6A15) | sc-57005 | 200 µg/ml | $322.00 |