Molecular structure of Fluvastatin, CAS Number: 93957-54-1
Fluvastatin (CAS 93957-54-1)
Alternate Names:
[R*,S*-(E)]-(±)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid, monosodium salt
Application:
Fluvastatin is a potent and competitive HMGCR inhibitor
CAS Number:
93957-54-1
Purity:
≥98%
Molecular Weight:
411.470
Molecular Formula:
C24H26FNO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fluvastatin is an HMGCR (HMG-CoA reductase) inhibitor. The compound is described to inhibit cell proliferation, illicit apoptosis, and protect against oxidative stress. Human hepatocellular carcinoma cell (HCC) studies indicate that Fluvastatin induces G2/M phase arrest. In the presence of Fluvastatin, HCC cells show a decrease of Bcl-2 and procaspase-9 expression, and an increase in Bax, cleaved caspase-3, and cytochrome c.
Fluvastatin (CAS 93957-54-1) References
- The phototoxicity of fluvastatin, an HMG-CoA reductase inhibitor, is mediated by the formation of a benzocarbazole-like photoproduct. | Viola, G., et al. 2010. Toxicol Sci. 118: 236-50. PMID: 20668001
- Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. | Makabe, S., et al. 2010. Atherosclerosis. 213: 377-84. PMID: 20864107
- Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells through mitochondria-operated pathway. | Zhang, W., et al. 2010. Indian J Exp Biol. 48: 1167-74. PMID: 21250597
- Fluvastatin upregulates the α 1C subunit of CaV1.2 channel expression in vascular smooth muscle cells via RhoA and ERK/p38 MAPK pathways. | Ouyang, QF., et al. 2014. Dis Markers. 2014: 237067. PMID: 25614710
- Fluvastatin prevents lung metastasis in triple-negative breast cancer by triggering autophagy via the RhoB/PI3K/mTOR pathway. | Xu, WH., et al. 2024. Exp Cell Res. 435: 113893. PMID: 38123008
- Lipid rafts disruption by statins negatively impacts the interaction between SARS-CoV-2 S1 subunit and ACE2 in intestinal epithelial cells. | El Khoury, M. and Naim, HY. 2023. Front Microbiol. 14: 1335458. PMID: 38260879
- Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes. | Al-Sabri, MH., et al. 2024. Sci Rep. 14: 3338. PMID: 38336990
- Fluvastatin Converts Human Macrophages into Foam Cells with Increased Inflammatory Response to Inactivated Mycobacterium tuberculosis H37Ra. | Montero-Vega, MT., et al. 2024. Cells. 13: PMID: 38534380
- Nanoparticles targeting mutant p53 overcome chemoresistance and tumor recurrence in non-small cell lung cancer. | Bi, YY., et al. 2024. Nat Commun. 15: 2759. PMID: 38553451
- Construction and characterization of a humanized SLCO1B1 rat model with its application in evaluating the uptake of different statins. | Zhang, Y., et al. 2024. Acta Pharm Sin B. 14: 1592-1604. PMID: 38572097
- Interplay of OATP1A/1B/2B1 uptake transporters and ABCB1 and ABCG2 efflux transporters in the handling of bilirubin and drugs. | Li, W., et al. 2024. Biomed Pharmacother. 175: 116644. PMID: 38692057
- Application of molecular dynamics-based pharmacophore and machine learning approaches to identify novel Mcl1 inhibitors through drug repurposing and mechanics research. | Wang, H., et al. 2024. Phys Chem Chem Phys. 26: 16107-16124. PMID: 38780456
- Highly variable biological effects of statins on cancer, non-cancer, and stem cells in vitro. | Gbelcová, H., et al. 2024. Sci Rep. 14: 11830. PMID: 38782983
Inhibitor of:
apoC1, apoD, ARF7, Ataxin-7, BSEP, CYB5R1, CYP2C8, EBPL, GBP8, GGPL-I, GP73, GRAMD1B, HHAT, HHIPL2, HMG-3, HMG-4, HMGCL, HMGCLL1, HMGCR, Kal1, LDLRAD3, LELP1, LIMP I, MARCH (membrane associated ring-CH-type finger), mHMGCS, MVD, Olr418, Peroxin 1, REP-2, SDPR, SKI-1, SOAT2, ST7, Su(fu), TM7SF2, and TMEM97.Activator of:
AADACL1, CYP2C9, CYP2J2, DPM1, ELOVL1, FTα, GGTase-Iα, LCAT, NSDHL, PMVK, Rab 34, Rho GAP p190, SCARA5, and ZNF202.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fluvastatin, 50 mg | sc-279169 | 50 mg | $250.00 |