Fluprostenol CAS: 40666-16-8
MF: C23H29F3O6
MW: 458.47
A prostaglandin F (FP) receptor agonist.

Fluprostenol (CAS 40666-16-8)

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备用名: (±)16-(m-Trifluoromethylphenoxy)-tetranor-prostaglandin F
应用; Fluprostenol is a prostaglandin F (FP) receptor agonist
CAS号码: 40666-16-8
纯度: 98%
分子量: 458.47
分子式: C23H29F3O6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

Fluprostenol is a PGFR (prostaglandin F (FP) receptor) agonist that is more selective than PGF (sc-201227). The compound can activate phosphorylation of ERK 2 (extracellular signal-regulated kinase (ERK)), p38-Mitogen-activated protein kinase (MAPK) and JNK3 (c-Jun N-terminal kinase (JNK)) in rat aortas. Studies have shown that it can induce phospholipase C and Ca+ mobilization in human myometrial cells and can decrease intraocular pressure (IOP) by improving aqueous humor outflow through the trabecular meshwork (TM) via inhibition of endothelin (ET)-1-dependent mechanisms. Fluprostenol also suppresses the expression of adipogenic genes in 3T3-L1 cells.


参考文献

1. Dukes, M., et al. 1974. Nature. 250: 330-331. PMID: 4853720
2. Carrasco, M.P., et al. 1996. J. Clin. Endocrinol. Metab. 81: 2104-2110. PMID: 8964835
3. Thieme, H., et al. 2006. Invest. Ophthalmol. Vis. Sci. 47: 938-945. PMID: 16505027
4. Rice, K.M., et al. 2010. Ann. Clin. Lab. Sci. 40: 26-31. PMID: 20124327

规划 :
Solution in ethanol (10 mg/ml)
物理状态 :
Liquid
溶解度 :
Soluble in ethanol (1 mg/100µL), acetone, and methanol.
保存 :
Store at -20° C
沸点 :
608
折射率 :
1.575
pK值 :
pKa: 4.76
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
1
PubChem CID :
6436637
MDL 号码 :
MFCD03427566
EC号码 :
200-578-6
SMILES :
C1[[email protected]]([[email protected]](C([[email protected]]1O)/C=C/[[email protected]@H](COC2=CC=CC(=C2)C(F)(F)F)O)C/C=C\\CCCC(=O)O)O

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