FGF Receptor Tyrosine Kinase Inhibitor IV, NP603

物理状态 :

Solid

溶解度 :

Soluble in DMSO ( ≥30 mg/ml).

保存 :

Store at 4° C

熔点 :

232-234° C

沸点 :

698.70° C at 760 mmHg (Predicted)

密度 :

1.29 g/cm³ (Predicted)

折射率 :

n²⁰_D 1.64 (Predicted)

IC50 :

FGFR1: IC₅₀ = 520 nM; PDGFRβ: IC₅₀ = 780 nM; VEGFR2: IC₅₀ = 930 nM; EGFR: IC₅₀ = >100 µM; FGF-2-induced proliferation: IC₅₀ = 18.2 µM (HUVEC₅₀ cultures)

pK值 :

pK_a: 4.60 (Predicted), pK_b: 2.28 (Predicted)

德国水公害等级 :

3

MDL 号码 :

MFCD18632551

SMILES :

COc1cc(OC)cc(c1)c1ccc2c(NC(=O)/C/2=C\\c2[nH]c(C)c(CCC(=O)O)c2C)c1