FAM65B 抗体 (3J7): sc-134289

FAM65B Antibody (3J7) is a high quality monoclonal FAM65B antibody (also designated FAM65B antibody) suitable for the detection of the FAM65B protein of human origin. FAM65B Antibody (3J7) is available as the non-conjugated anti-FAM65B antibody. FAM65B, also known as C6orf32, DIFF28 or PL48, is a 1,068 amino acid protein that belongs to the FAM65 family. FAM65B exists as two alternatively spliced isoforms; isoform 1 is found in brain while isoform 2 is expressed in fetal primary myoblasts during differentiation. Isoform 2 may be important for cellular differentiation, filopodia formation and cytoskeletal rearrangement. Cells missing isoform 2 have a large reduction of myotube formation, yet overexpression induces filopodial formation. The gene encoding FAM65B maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson′s disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.