FAHD2A Antibody (H-11): sc-515367

FAHD2A Antibody (H-11) is a mouse monoclonal IgG3 kappa light chain antibody that detects FAHD2A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-FAHD2A antibody (H-11) is available as the non-conjugated form. FAHD2A protein, also known as CGI-105, is a 314 amino acid protein that possesses hydrolase activity and belongs to the fumarylacetoacetate hydrolase family. FAHD2A plays a crucial role in various metabolic processes, particularly in the breakdown of certain amino acids, which is essential for maintaining cellular homeostasis and preventing toxic metabolite accumulation. FAHD2A activity depends on calcium and magnesium ions as cofactors, highlighting these minerals′ importance in enzymatic reactions. FAHD2A is encoded by a gene located on human chromosome 2, a region housing over 1,400 genes and associated with various genetic disorders. Chromosome 2 has been implicated in conditions such as Harlequin ichthyosis and Alström syndrome, underscoring the importance of understanding chromosome 2-encoded proteins in human health and disease.

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FAHD2A Antibody (H-11) References:

1. An ATP-binding cassette gene (ABCG5) from the ABCG (White) gene subfamily maps to human chromosome 2p21 in the region of the Sitosterolemia locus.  |  Shulenin, S., et al. 2001. Cytogenet Cell Genet. 92: 204-8. PMID: 11435688
2. Mutation of ALMS1, a large gene with a tandem repeat encoding 47 amino acids, causes Alström syndrome.  |  Hearn, T., et al. 2002. Nat Genet. 31: 79-83. PMID: 11941370
3. X-ray structure of fumarylacetoacetate hydrolase family member Homo sapiens FLJ36880.  |  Manjasetty, BA., et al. 2004. Biol Chem. 385: 935-42. PMID: 15551868
4. Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis.  |  Kelsell, DP., et al. 2005. Am J Hum Genet. 76: 794-803. PMID: 15756637
5. Differential expression of murine CGI-105 gene in 3T3-L1 cells by adrenocorticotropic hormones.  |  Choi, H., et al. 2005. Cell Biol Int. 29: 177-9. PMID: 15774318
6. Punctuated duplication seeding events during the evolution of human chromosome 2p11.  |  Horvath, JE., et al. 2005. Genome Res. 15: 914-27. PMID: 15965031
7. Rescue of lethal hepatic failure by hepatized lymph nodes in mice.  |  Hoppo, T., et al. 2011. Gastroenterology. 140: 656-666.e2. PMID: 21070777
8. Identification of FAH domain-containing protein 1 (FAHD1) as oxaloacetate decarboxylase.  |  Pircher, H., et al. 2015. J Biol Chem. 290: 6755-62. PMID: 25575590
9. Structural and functional comparison of fumarylacetoacetate domain containing protein 1 in human and mouse.  |  Weiss, AKH., et al. 2020. Biosci Rep. 40: PMID: 32068790
10. Investigating the causal association between obesity and risk of hepatocellular carcinoma and underlying mechanisms.  |  Chen, Z., et al. 2024. Sci Rep. 14: 15717. PMID: 38977823
11. An alphoid DNA sequence conserved in all human and great ape chromosomes: evidence for ancient centromeric sequences at human chromosomal regions 2q21 and 9q13.  |  Baldini, A., et al. 1993. Hum Genet. 90: 577-83. PMID: 8444464
12. Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found at chromosome 2p21.  |  Patel, SB., et al. 1998. J Clin Invest. 102: 1041-4. PMID: 9727073

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FAHD2A Antibody (H-11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-FAHD2A Antibody (H-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FAHD2A Antibody (H-11) Specifications

Alternate Product Name: FAHD2A

Product Clone Name: H-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 160-279

Epitope Target: FAHD2A

Epitope Species: human

Product Reactivity/Detection: FAHD2A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for FAHD2A Antibody (H-11): N/A