Molecular structure of Eletriptan-d3, CAS Number: 143322-58-1 (unlabeled)
Eletriptan-d3 (CAS 143322-58-1 (unlabeled))
Application:
Eletriptan-d3 is labeled Eletriptan - a serotonin 5-HTIB/ID receptor agonist
CAS Number:
143322-58-1 (unlabeled)
Molecular Weight:
385.54
Molecular Formula:
C22H23D3N2O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Eletriptan-d3 is a indole-pyrolidine conjugate that is labeled with deuterium at the N-methyl group of the pyrolidine moiety. This compound has shown 5-HTIB/ID receptor agonism that is slightly less potent, but comparable to sumatriptan (sc-204314). Eletriptan, like 5-HT and sumatriptan potently contracted saphenous vein (pEC50: 6.3, 6.9 and 6.1, respectively) and basilar artery (pEC50 7.2, 7.5 and 6.8, respectively).
Eletriptan-d3 (CAS 143322-58-1 (unlabeled)) References
- Characterisation of the contractile activity of eletriptan at the canine vascular 5-HT1B receptor. | Gupta, P., et al. 1999. Eur J Pharmacol. 367: 283-90. PMID: 10079003
- Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. | Napier, C., et al. 1999. Eur J Pharmacol. 368: 259-68. PMID: 10193663
- Eletriptan in acute migraine: a double-blind, placebo-controlled comparison to sumatriptan. Eletriptan Steering Committee. | Goadsby, PJ., et al. 2000. Neurology. 54: 156-63. PMID: 10636142
- Porcine carotid vascular effects of eletriptan (UK-116,044): a new 5-HT1B/1D receptor agonist with anti-migraine activity. | Willems, E., et al. 1998. Naunyn Schmiedebergs Arch Pharmacol. 358: 212-9. PMID: 9750007
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Eletriptan-d3, 1 mg | sc-218299 | 1 mg | $380.00 |