E2F-6 Antibody (E-3): sc-398677
- E2F-6 Antibody (E-3) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 232-281 of E2F-6 of human origin
- recommended for detection of E2F-6 of human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-398677 X, 200 µg/0.1 ml)
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for E2F-6 Antibody (E-3) for WB applications. These reagents are now offered in bundles with E2F-6 Antibody (E-3) (see ordering information below).
E2F-6 Antibody (E-3) is a mouse monoclonal IgG2b antibody that detects E2F-6 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). E2F-6 is a member of the E2F family of transcription factors, which play a crucial role in regulating cell cycle and gene expression. Specifically, E2F-6 functions as a transcriptional repressor, inhibiting the expression of genes necessary for the transition from G1 phase to S phase of the cell cycle. This regulation is vital for maintaining proper cell proliferation and preventing uncontrolled cell growth, which can lead to tumorigenesis. E2F-6 achieves repressive function by forming complexes with other proteins, including retinoblastoma protein (Rb), a key regulator of cell cycle progression. The interaction between E2F-6 and Rb highlights the importance of E2F-6 in cell cycle control and cancer biology. Anti-E2F-6 antibody (E-3) is an essential tool for researchers studying mechanisms of cell cycle regulation and implications of E2F family proteins in various diseases.
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E2F-6 Antibody (E-3) References:
- The NRF-1/alpha-PAL transcription factor regulates human E2F6 promoter activity. | Kherrouche, Z., et al. 2004. Biochem J. 383: 529-36. PMID: 15257658
- Activating E2Fs mediate transcriptional regulation of human E2F6 repressor. | Lyons, TE., et al. 2006. Am J Physiol Cell Physiol. 290: C189-99. PMID: 16107498
- The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy. | Westendorp, B., et al. 2012. FASEB J. 26: 2569-79. PMID: 22403008
- E2f6-mediated repression of the meiotic Stag3 and Smc1β genes during early embryonic development requires Ezh2 and not the de novo methyltransferase Dnmt3b. | Leseva, M., et al. 2013. Epigenetics. 8: 873-84. PMID: 23880518
- E2F6 Impairs Glycolysis and Activates BDH1 Expression Prior to Dilated Cardiomyopathy. | Major, JL., et al. 2017. PLoS One. 12: e0170066. PMID: 28085920
- MicroRNA-424/E2F6 feedback loop modulates cell invasion, migration and EMT in endometrial carcinoma. | Lu, Z., et al. 2017. Oncotarget. 8: 114281-114291. PMID: 29371986
- Nuclear receptor TLX regulates islet beta cell proliferation via E2F6. | Shi, X., et al. 2019. Biochem Biophys Res Commun. 513: 560-566. PMID: 30981507
- miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6. | An, Y., et al. 2020. Cancer Cell Int. 20: 237. PMID: 32536825
- Long noncoding RNA SLC9A3‑AS1 increases E2F6 expression by sponging microRNA‑486‑5p and thus facilitates the oncogenesis of nasopharyngeal carcinoma. | Li, J., et al. 2021. Oncol Rep. 46: PMID: 34165171
- circ_0089153 exacerbates breast cancer cells proliferation and metastasis via sponging miR-2467-3p/E2F6. | Gao, SL., et al. 2022. Environ Toxicol. 37: 1458-1471. PMID: 35225430
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E2F-6 Antibody (E-3) | sc-398677 | 200 µg/ml | $322.00 | |||
E2F-6 Antibody (E-3): m-IgGκ BP-HRP Bundle | sc-536122 | 200 µg Ab; 40 µg BP | $361.00 | |||
E2F-6 Antibody (E-3): m-IgG2b BP-HRP Bundle | sc-549516 | 200 µg Ab; 10 µg BP | $361.00 | |||
E2F-6 Antibody (E-3) X | sc-398677 X | 200 µg/0.1 ml | $322.00 |