Molecular structure of Dolastatin 15, CAS Number: 123884-00-4
Dolastatin 15 (CAS 123884-00-4)
See product citations (4)
Application:
Dolastatin 15 is an apoptotic agent through Blc-2 phosphorylation
CAS Number:
123884-00-4
Purity:
≥98%
Molecular Weight:
837.06
Molecular Formula:
C45H68N6O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dolastatin 15 is a member of the dolastatin family. Dolastatins are marine natural products isolated from the sea hare Dolabella auricularia with a structure related to Dolastin 10. Dolastatin 15 is an anti-neoplastic pseudopeptide that inhibits tubulin-dependent GTP hydrolysis to tubulin but has been shown to bind to the RZX/MAY region. The compound weakly inhibits microtubule assembly through binding to the vinca domain of tubulin and induces apoptosis through Bcl-2 phosphorylation in several malignant cell types. Potent inhibitor of the proliferation of murine and cancer cell lines as well as that of hematopoietic progenitor cells. When added to leukemia cultures Dolastin 15 inhibited both immunoglobulin production and cell proliferation.
Dolastatin 15 (CAS 123884-00-4) References
- Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography. | Cruz-Monserrate, Z., et al. 2003. Eur J Biochem. 270: 3822-8. PMID: 12950266
- Dolastatin 10 and dolastatin 15: effects of two natural peptides on growth and differentiation of leukemia cells. | Steube, KG., et al. 1992. Leukemia. 6: 1048-53. PMID: 1405759
- Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules. | Bai, R., et al. 1992. Biochem Pharmacol. 43: 2637-45. PMID: 1632820
- A natural peptide, dolastatin 15, induces G2/M cell cycle arrest and apoptosis of human multiple myeloma cells. | Sato, M., et al. 2007. Int J Oncol. 30: 1453-9. PMID: 17487366
- Intracellular activation and deactivation of tasidotin, an analog of dolastatin 15: correlation with cytotoxicity. | Bai, R., et al. 2009. Mol Pharmacol. 75: 218-26. PMID: 18927208
- Dolastatin 15, a mollusk linear peptide, and Celecoxib, a selective cyclooxygenase-2 inhibitor, prevent preneoplastic colonic lesions and induce apoptosis through inhibition of the regulatory transcription factor NF-κB and an inflammatory protein, iNOS. | Piplani, H., et al. 2012. Eur J Cancer Prev. 21: 511-22. PMID: 22441428
- Up-regulation of p53 and mitochondrial signaling pathway in apoptosis by a combination of COX-2 inhibitor, Celecoxib and Dolastatin 15, a marine mollusk linear peptide in experimental colon carcinogenesis. | Piplani, H., et al. 2013. Mol Carcinog. 52: 845-58. PMID: 22623379
- Dolastatin 15 from a Marine Cyanobacterium Suppresses HIF-1α Mediated Cancer Cell Viability and Vascularization. | Ratnayake, R., et al. 2020. Chembiochem. 21: 2356-2366. PMID: 32237262
- Phycochemistry and bioactivity of cyanobacterial secondary metabolites. | Srivastava, R., et al. 2022. Mol Biol Rep. 49: 11149-11167. PMID: 36161579
- The bcl-2 and p53 oncoproteins can be modulated by bryostatin 1 and dolastatins in human diffuse large cell lymphoma. | Maki, A., et al. 1995. Anticancer Drugs. 6: 392-7. PMID: 7670136
- Growth inhibition of human lymphoma cell lines by the marine products, dolastatins 10 and 15. | Beckwith, M., et al. 1993. J Natl Cancer Inst. 85: 483-8. PMID: 8445676
- Effects of dolastatins on human B-lymphocytic leukemia cell lines. | Hu, ZB., et al. 1993. Leuk Res. 17: 333-9. PMID: 8487581
- Dolastatin 15 induces apoptosis and BCL-2 phosphorylation in small cell lung cancer cell lines. | Ali, MA., et al. 1998. Anticancer Res. 18: 1021-6. PMID: 9615758
Inhibitor of:
Tubulin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dolastatin 15, 1 mg | sc-201449 | 1 mg | $305.00 |