DNCLI1 Antibody (H-7): sc-514141

DNCLI1 Antibody (H-7) is a mouse monoclonal IgA kappa light chain antibody that detects DNCLI1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DNCLI1 (H-7) antibody is available as the non-conjugated form. DNCLI1 protein, also known as Cytoplasmic dynein 1 light intermediate chain 1, functions as a crucial component of the dynein motor complex, essential for various cellular processes, including intracellular transport and mitosis. This 523 amino acid protein is integral to dynein structure, consisting of multiple heavy, intermediate, and light chains that work together to facilitate cellular cargo movement along microtubules. DNCLI1 plays a significant role in binding dynein heavy chains to chromosomes or membranous organelles, thereby influencing cellular transport dynamics and dynein enzymatic activity regulation. Understanding DNCLI1′s importance in these processes provides insights into potential implications in cellular function and disease mechanisms, making anti-DNCLI1 antibody (H-7) an invaluable tool for studying dynein-related activities in various biological contexts.

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DNCLI1 Antibody (H-7) References:

1. Direct interaction of pericentrin with cytoplasmic dynein light intermediate chain contributes to mitotic spindle organization.  |  Purohit, A., et al. 1999. J Cell Biol. 147: 481-92. PMID: 10545494
2. Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin.  |  Tynan, SH., et al. 2000. J Biol Chem. 275: 32763-8. PMID: 10893222
3. The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate chain-1.  |  Bielli, A., et al. 2001. Biochem Biophys Res Commun. 281: 1141-53. PMID: 11243854
4. A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity.  |  Ligon, LA., et al. 2004. J Biol Chem. 279: 19201-8. PMID: 14985359
5. Potential role for phosphorylation in differential regulation of the assembly of dynein light chains.  |  Song, Y., et al. 2007. J Biol Chem. 282: 17272-9. PMID: 17428790
6. Dyneins across eukaryotes: a comparative genomic analysis.  |  Wickstead, B. and Gull, K. 2007. Traffic. 8: 1708-1721. PMID: 17897317
7. Interaction of the DYNLT (TCTEX1/RP3) light chains and the intermediate chains reveals novel intersubunit regulation during assembly of the dynein complex.  |  Lo, KW., et al. 2007. J Biol Chem. 282: 36871-8. PMID: 17965411
8. Dynein light intermediate chain: an essential subunit that contributes to spindle checkpoint inactivation.  |  Mische, S., et al. 2008. Mol Biol Cell. 19: 4918-29. PMID: 18799620

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DNCLI1 Antibody (H-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-DNCLI1 Antibody (H-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DNCLI1 Antibody (H-7) Specifications

Alternate Product Name: DNCLI1

Product Clone Name: H-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgA kappa light chain

Amino Acids: 5-23

Epitope Target: DNCLI1

Epitope Species: human

Product Reactivity/Detection: DNCLI1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgA kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for DNCLI1 Antibody (H-7): P: Blocking Peptide