Date published: 2025-9-6

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DBC-1 抗体 (H-2): sc-166733

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说明书
  • DBC-1 抗体 H-2 是小鼠单克隆 IgG3 κ,DBC-1抗体, 在5篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的DBC-1的内部区域内的氨基酸750-768之间
  • 推荐用于 DBC-1 of human origin, 2610301G19Rik of mouse origin and the corresponding rat homolog WB, IP, IF, IHC(P) 和 ELISA检测
  • 关于如何获取DBC-1 (H-2): sc-166733免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG3 BP-HRPm-IgGκ BP-HRP是DBC-1抗体(H-2)在WB and IHC(P)应用中的首选二次检测试剂。这些试剂现在与DBC-1 抗体(H-2)捆绑销售(见下文订购信息)。

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関連項目

DBC-1抗体(H-2)是一种IgG3 κ小鼠单克隆DBC-1抗体,可通过WB、IP、IF、IHC(P)和ELISA检测人源DBC-1蛋白、小鼠源2610301G19Rik蛋白及其相应的大鼠同源物。DBC-1抗体(H-2)可作为非偶联的抗DBC-1抗体提供。DBC-1(乳腺癌基因1蛋白被删除),又称为p30 DBC蛋白,是位于染色体8(8p21-8p23)区域内的基因之一,在某些乳腺癌中呈纯合缺失。DBC-1含有核定位信号、N端亮氨酸拉链、EF手和C端卷曲卷区。DBC-1与DIS密切相关,但缺少SAP领域。在TNFα介导的死亡信号中,内源性DBC-1经历半胱天冬酶依赖性处理,产生包括蛋白C末端的DBC-1 p120和p66,这两者均迁移到细胞质中。DBC-1 p120形式的过表达会导致线粒体聚集和基质凝缩,并增加细胞对TNFα介导的凋亡的敏感性。此外,DBC-1可直接与未配体的ERα相互作用,稳定其表达,从而协助抑制凋亡并促进激素独立的细胞生长。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

DBC-1 抗体 (H-2) 参考文献:

  1. DBC2,乳腺癌肿瘤抑制基因的候选者。  |  Hamaguchi, M., et al. 2002. Proc Natl Acad Sci U S A. 99: 13647-52. PMID: 12370419
  2. 套细胞淋巴瘤模型基因组的全基因组阵列 CGH 图谱分析。  |  de Leeuw, RJ., et al. 2004. Hum Mol Genet. 13: 1827-37. PMID: 15229187
  3. 在肿瘤坏死因子-α介导的死亡信号传导过程中,Caspase 依赖性处理激活了乳腺癌-1 中删除的促凋亡活性。  |  Sundararajan, R., et al. 2005. Oncogene. 24: 4908-20. PMID: 15824730
  4. B 细胞淋巴瘤中 8p21.3 染色体缺失的特征:TRAIL-R1和TRAIL-R2作为候选剂量依赖性肿瘤抑制基因  |  Rubio-Moscardo, F., et al. 2005. Blood. 106: 3214-22. PMID: 16051735
  5. 压力刺激乳腺癌细胞粘附,与细胞周期和凋亡调控蛋白(CARP)-1 对局灶粘附激酶的调控无关。  |  Downey, C., et al. 2006. Am J Surg. 192: 631-5. PMID: 17071197
  6. 利用 TAP/MudPIT 组合方法大规模鉴定 c-MYC 相关蛋白。  |  Koch, HB., et al. 2007. Cell Cycle. 6: 205-17. PMID: 17314511
  7. DBC-1对雌激素受体α蛋白水平和存活功能的调节作用  |  Trauernicht, AM., et al. 2007. Mol Endocrinol. 21: 1526-36. PMID: 17473282
  8. 头颈部鳞状细胞癌 8p21.3-p22 频发杂合性缺失区的基因组评估。  |  Ye, H., et al. 2007. Cancer Genet Cytogenet. 176: 100-6. PMID: 17656251
  9. DBC1/CCAR2 参与了雄激素受体的稳定和骨肉瘤的进展。  |  Wagle, S., et al. 2015. Sci Rep. 5: 13144. PMID: 26249023
  10. 细胞毒性化疗诱导的IL-6与无肿瘤雌性小鼠瘦体重和脂肪量的减少有关。  |  Sarwar, Z., et al. 2022. J Biol Chem. 298: 101496. PMID: 34921839
  11. SUMO1调控的DBC1促进p53依赖性应激诱导的晶状体上皮细胞凋亡  |  Wang, Y., et al. 2023. Aging (Albany NY). 15: 8812-8832. PMID: 37683133
  12. DBC1通过促进肌原纤维生成和防止肌纤维萎缩来维持骨骼肌的完整性。  |  Liang, N., et al. 2024. J Cachexia Sarcopenia Muscle. 15: 255-269. PMID: 38062876

订购信息

产品名称产品编号规格价格数量收藏夹

DBC-1 抗体 (H-2)

sc-166733
200 µg/ml
$316.00

DBC-1 (H-2): m-IgGκ BP-HRP 套装

sc-521726
200 µg Ab, 40 µg BP
$354.00

DBC-1 (H-2): m-IgG3 BP-HRP 套装

sc-550338
200 µg Ab; 40 µg BP
$354.00

DBC-1 (H-2) 中和勝肽

sc-166733 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-166733 P appropriate for?

Asked by: Randy McDonald
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-25
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Rated 1 out of 5 by from Weak antibodyVery weak antibody. Band visible at 1:100 dilution only after 1-hour exposition on film. Tested in a HCT116 whole cell lysate.
Date published: 2018-09-03
Rated 3 out of 5 by from Not quite suitable for wb of rat protein1:100 diluted for wb of rat heart protein,the band is not quite clear.
Date published: 2017-12-30
Rated 5 out of 5 by from DBC-1抗体评论刚开始很难出条带,摸条件调试了好几次之后就好了很多,加大稀释比例之后就好了,总体评价还不错,条带很清晰!
Date published: 2017-12-07
Rated 1 out of 5 by from can not detect specific band by WBit can not detect a specific band by WB in our lab.
Date published: 2017-09-18
Rated 5 out of 5 by from good antibodya good antibody for both human and mice samples, but not confirmed with knockdown yet.
Date published: 2017-02-28
Rated 5 out of 5 by from Excellent immunofluorescence nuclear stainingExcellent immunofluorescence nuclear staining in formalin-fixed HepG2 cells. -SCBT QC
Date published: 2015-05-14
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DBC-1 抗体 (H-2) is rated 3.6 out of 5 by 7.
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