Date published: 2026-10-19
访问圣克鲁斯动物健康

1-800-457-3801

SCBT Portrait Logo
Seach Input
联系我们
登陆账户
快速订购
购物车 (0)
DBC-1 Antibody (H-2) - Western Blotting - Image 128612
DBC-1 抗体 (H-2): sc-166733. A549 核提取物 (A) 和 T-47D 全细胞裂解液 (B) 中 DBC-1 表达的 Western 印迹分析.
DBC-1 抗体 (H-2): sc-166733. A549 核提取物 (A) 和 T-47D 全细胞裂解液 (B) 中 DBC-1 表达的 Western 印迹分析.

DBC-1 抗体 (H-2): sc-166733

3.6(7)
寫評論提問
说明书
  • DBC-1 抗体 H-2 是小鼠单克隆 IgG3 κ，DBC-1抗体, 在5篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的DBC-1的内部区域内的氨基酸750-768之间
  • 推荐用于 DBC-1 of human origin, 2610301G19Rik of mouse origin and the corresponding rat homolog WB, IP, IF, IHC(P) 和 ELISA检测
  • m-IgG3 BP-HRP和m-IgGκ BP-HRP是DBC-1 Antibody (H-2) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂，这些试剂现与DBC-1 Antibody (H-2) 打包提供（请参阅下面的订购信息）。
Gene Editing Promo Banner

快捷链接

相关产品
描述
基因信息
说明书与实验方案
研究信息

関連項目

附加DBC抗体，包括DBC-1和DBC-2

DBC-1抗体（H-2）是一种IgG3 κ小鼠单克隆DBC-1抗体，可通过WB、IP、IF、IHC(P)和ELISA检测人源DBC-1蛋白、小鼠源2610301G19Rik蛋白及其相应的大鼠同源物。DBC-1抗体（H-2）可作为非偶联的抗DBC-1抗体提供。DBC-1（乳腺癌基因1蛋白被删除），又称为p30 DBC蛋白，是位于染色体8（8p21-8p23）区域内的基因之一，在某些乳腺癌中呈纯合缺失。DBC-1含有核定位信号、N端亮氨酸拉链、EF手和C端卷曲卷区。DBC-1与DIS密切相关，但缺少SAP领域。在TNFα介导的死亡信号中，内源性DBC-1经历半胱天冬酶依赖性处理，产生包括蛋白C末端的DBC-1 p120和p66，这两者均迁移到细胞质中。DBC-1 p120形式的过表达会导致线粒体聚集和基质凝缩，并增加细胞对TNFα介导的凋亡的敏感性。此外，DBC-1可直接与未配体的ERα相互作用，稳定其表达，从而协助抑制凋亡并促进激素独立的细胞生长。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

DBC-1 抗体 (H-2) 参考文献:

  1. DBC2，乳腺癌肿瘤抑制基因的候选者。  |  Hamaguchi, M., et al. 2002. Proc Natl Acad Sci U S A. 99: 13647-52. PMID: 12370419
  2. 套细胞淋巴瘤模型基因组的全基因组阵列 CGH 图谱分析。  |  de Leeuw, RJ., et al. 2004. Hum Mol Genet. 13: 1827-37. PMID: 15229187
  3. 在肿瘤坏死因子-α介导的死亡信号传导过程中，Caspase 依赖性处理激活了乳腺癌-1 中删除的促凋亡活性。  |  Sundararajan, R., et al. 2005. Oncogene. 24: 4908-20. PMID: 15824730
  4. B 细胞淋巴瘤中 8p21.3 染色体缺失的特征：TRAIL-R1和TRAIL-R2作为候选剂量依赖性肿瘤抑制基因  |  Rubio-Moscardo, F., et al. 2005. Blood. 106: 3214-22. PMID: 16051735
  5. 压力刺激乳腺癌细胞粘附，与细胞周期和凋亡调控蛋白（CARP）-1 对局灶粘附激酶的调控无关。  |  Downey, C., et al. 2006. Am J Surg. 192: 631-5. PMID: 17071197
  6. 利用 TAP/MudPIT 组合方法大规模鉴定 c-MYC 相关蛋白。  |  Koch, HB., et al. 2007. Cell Cycle. 6: 205-17. PMID: 17314511
  7. DBC-1对雌激素受体α蛋白水平和存活功能的调节作用  |  Trauernicht, AM., et al. 2007. Mol Endocrinol. 21: 1526-36. PMID: 17473282
  8. 头颈部鳞状细胞癌 8p21.3-p22 频发杂合性缺失区的基因组评估。  |  Ye, H., et al. 2007. Cancer Genet Cytogenet. 176: 100-6. PMID: 17656251
  9. DBC1/CCAR2 参与了雄激素受体的稳定和骨肉瘤的进展。  |  Wagle, S., et al. 2015. Sci Rep. 5: 13144. PMID: 26249023
  10. 细胞毒性化疗诱导的IL-6与无肿瘤雌性小鼠瘦体重和脂肪量的减少有关。  |  Sarwar, Z., et al. 2022. J Biol Chem. 298: 101496. PMID: 34921839
  11. SUMO1调控的DBC1促进p53依赖性应激诱导的晶状体上皮细胞凋亡  |  Wang, Y., et al. 2023. Aging (Albany NY). 15: 8812-8832. PMID: 37683133
  12. DBC1通过促进肌原纤维生成和防止肌纤维萎缩来维持骨骼肌的完整性。  |  Liang, N., et al. 2024. J Cachexia Sarcopenia Muscle. 15: 255-269. PMID: 38062876

订购信息

产品名称产品编号规格价格数量收藏夹

DBC-1 抗体 (H-2)

sc-166733
200 µg/ml
$322.00

DBC-1 (H-2): m-IgGκ BP-HRP 套装

sc-521726
200 µg Ab, 40 µg BP
$361.00

DBC-1 (H-2): m-IgG3 BP-HRP 套装

sc-550338
200 µg Ab; 40 µg BP
$361.00

DBC-1 (H-2) 中和勝肽

sc-166733 P
100 µg/0.5 ml
$69.00

What application is the blocking peptide sc-166733 P appropriate for?

Asked by: Randy McDonald
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-25
  • y_2026, m_10, d_19, h_5CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.48
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_zh_CN, sid_166733, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 103ms
  • QUESTIONS, PRODUCT
Rated 4 out of 5 by Nyanko from This antibody functions well for western blottingWe used this antibody functions well for western blotting. The specificity of the antibody was confirmed with DBC1 knockout cell line.
Date published: 2026-09-02
Rated 1 out of 5 by zusl from Weak antibodyVery weak antibody. Band visible at 1:100 dilution only after 1-hour exposition on film. Tested in a HCT116 whole cell lysate.
Date published: 2018-09-03
Rated 3 out of 5 by 小新贝贝 from Not quite suitable for wb of rat protein1:100 diluted for wb of rat heart protein,the band is not quite clear.
Date published: 2017-12-30
Rated 5 out of 5 by star123 from DBC-1抗体评论刚开始很难出条带，摸条件调试了好几次之后就好了很多，加大稀释比例之后就好了，总体评价还不错，条带很清晰！
Date published: 2017-12-07
Rated 1 out of 5 by danni from can not detect specific band by WBit can not detect a specific band by WB in our lab.
Date published: 2017-09-18
Rated 5 out of 5 by maryzhang from good antibodya good antibody for both human and mice samples, but not confirmed with knockdown yet.
Date published: 2017-02-28
Rated 5 out of 5 by MS from Excellent immunofluorescence nuclear stainingExcellent immunofluorescence nuclear staining in formalin-fixed HepG2 cells. -SCBT QC
Date published: 2015-05-14
  • y_2026, m_10, d_18, h_6
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.48
  • cp_1, bvpage1
  • co_hasreviews, tv_1, tr_7
  • loc_zh_CN, sid_166733, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 9ms
  • REVIEWS, PRODUCT
DBC-1 抗体 (H-2) is rated 3.6 out of 5 by 8.
  • y_2026, m_10, d_18, h_6
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.48
  • cp_1, bvpage1
  • co_hasreviews, tv_1, tr_7
  • loc_zh_CN, sid_166733, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 95ms
  • REVIEWS, PRODUCT
1-800-457-3801
访问 Santa Cruz Animal Health|访问 San Juan Ranch
Santa Cruz Biotechnology, Inc. 是生物医学研究市场产品开发的世界领导者。请拨打1-800-457-3801联系我们。
版权所有© 2007-2026 Santa Cruz Biotechnology, Inc. 保留所有权利。”Santa Cruz Biotechnology” 和Santa Cruz Biotechnology, Inc.的商标，”Santa Cruz Animal Health”, “San Juan Ranch”, “Supplement of Champions”, San Juan Ranch的商标，”UltraCruz”, “ChemCruz”, “ImmunoCruz”, “ExactaCruz”, 和 “EZ Touch”是Santa Cruz Biotechnology, Inc.的注册商标。所有商标均为其各自所有者的财产。