Cytosine β-D-arabinofuranoside hydrochloride CAS: 69-74-9
MF: C9H13N3O5•HCl
MW: 279.68
A DNA synthesis inhibitor and anti-leukemic agent.

Cytosine β-D-arabinofuranoside hydrochloride (CAS 69-74-9)

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同义词: arabinofuranosylcytosine
应用; A DNA synthesis inhibitor and anti-leukemic agent
CAS号码: 69-74-9
纯度: ≥99%
分子量: 279.68
分子式: C9H13N3O5•HCl
* 参考分析证明 大量特定数据 (包括水 含量).
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Cytosine β-D-arabinofuranoside hydrochloride is an anti-leukemic agent which binds to topoisomerase I, resulting in DNA fragmentation and inhibition of replication. This compound does not have any effects on RNA synthesis. Cytosine β-D-arabinofuranoside hydrochloride functions as a ligand with strong affinity and selectivity for the translocator protein (TSPO). Studies suggest that cytosine β-D-arabinofuranoside hydrochloride can down-regulate deoxycytidine kinase in acute myeloid leukemia murine cell lines, which inhibits the phosphorylation of several deoxyribonucleosides. Furthermore, cytosine β-D-arabinofuranoside hydrochloride can be inhibited in myeloid leukemic cells via suppression of ENT1 promoter activity, responsible for transporting cytosine β-D-arabinofuranoside into the cell.


参考文献

1. Jin, G., et al. 2009. Biochem. Biophys. Res. Commun. 390: 1001-1006. PMID: 19853583
2. Rathe, S.K. and Largaespada, D.A. 2010. Leukemia. 24: 1513-1515. PMID: 20508618
3. Denora, N., et al. 2010. Mol. Pharm. 7: 2255-2269. PMID: 20958082

外观 :
Crystalline powder
物理状态 :
Solid
溶解度 :
Soluble in water (50 mg/ml).
保存 :
Store at 4° C
熔点 :
197-198° C (lit.)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
6252
SMILES :

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PMID: # 24375454  2014. Eur. J. Immunol. 44: 1108-18.

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