Date published: 2025-9-7

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Cyr61/CCN1 抗体 (A-10): sc-374129

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说明书
  • Cyr61/CCN1 抗体 A-10 是小鼠单克隆 IgG1 κ,Cyr61/CCN1抗体, 在27篇文献中引用,规格为200 µg/ml
  • 免疫human物种的Cyr61的氨基酸163-240
  • Cyr61/CCN1 抗体 (A-10) 推荐用于WB, IP, IF, IHC(P) 和 ELISA,检测human 来源的 Cyr61
  • 抗Cyr61/CCN1抗体(A-10)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Cyr61/CCN1 (A-10): sc-374129免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 Cyr61/CCN1 抗体 (A-10) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Cyr61/CCN1 抗体 (A-10) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

Cyr61抗体(A-10)是一种IgG1 κ小鼠单克隆Cyr61抗体(也称为CCN1抗体或CYR61抗体),可通过WB、IP、IF、IHC(P)和ELISA检测人源Cyr61蛋白。Cyr61抗体(A-10)既有非偶联的抗Cyr61抗体形式,也有多种偶联形式的抗Cyr61抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。Cyr61是一种由生长因子诱导的即刻早期基因编码的分泌型肝素结合蛋白,与细胞外基质和结缔组织相关。Cyr61是一个独特的促血管生成和血管生成调节因子家族的成员,被指定为CCN蛋白,其中包括结缔组织生长因子(CTGF)和小鼠Cyr61同源物Fisp12。作为一种血管生成诱导剂,Cyr61与细胞表面受体整合素αvβ3结合,然后刺激细胞粘附和迁移,并促进人血管内皮细胞的DNA合成。Cyr61在血管生长、伤口愈合和软骨细胞分化过程中表达升高。Cyr61在多种肿瘤中也有发现,因为它能诱导肿瘤生长,并作为肿瘤进展的标志物。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cyr61/CCN1 抗体 (A-10) 参考文献:

  1. Fisp12/小鼠结缔组织生长因子通过整合素αavbeta3介导内皮细胞粘附和迁移,促进内皮细胞存活,并诱导体内血管生成。  |  Babic, AM., et al. 1999. Mol Cell Biol. 19: 2958-66. PMID: 10082563
  2. 人血小板对 Cyr61 和 Fisp12/小鼠结缔组织生长因子的活化依赖性粘附是通过整合素 alpha(IIb)beta(3) 介导的。  |  Jedsadayanmata, A., et al. 1999. J Biol Chem. 274: 24321-7. PMID: 10446209
  3. 生长因子诱导的即刻早期基因 cyr61 的表达与小鼠胚胎发育过程中的软骨形成有关。  |  O'Brien, TP. and Lau, LF. 1992. Cell Growth Differ. 3: 645-54. PMID: 1419914
  4. Cyr61是前列腺癌的潜在预后标志物。  |  Terada, N., et al. 2012. Asian J Androl. 14: 405-8. PMID: 22343491
  5. 生长因子诱导型即时早期基因 cyr61 的表达。  |  O'Brien, TP., et al. 1990. Mol Cell Biol. 10: 3569-77. PMID: 2355916
  6. Cyr61表达与结直肠癌患者的预后相关。  |  Jeong, D., et al. 2014. BMC Cancer. 14: 164. PMID: 24606730
  7. 结肠癌细胞中3-巯基丙酮酸硫转移酶对CyR61表达和释放的调节。  |  Ascenção, K., et al. 2022. Redox Biol. 56: 102466. PMID: 36113340
  8. 血清CYR61作为改善乳腺癌诊断的潜在生物标志物。  |  Lin, Z., et al. 2022. Biomark Med. 16: 1121-1128. PMID: 36606458
  9. CYR61通过激活上皮-间质转化促进结直肠癌的进展。  |  Rasool, S., et al. 2023. Am J Cancer Res. 13: 4872-4887. PMID: 37970355
  10. CYR61在雌激素受体阳性乳腺癌中的预后意义和肿瘤抑制功能。  |  Zhang, C., et al. 2023. Front Immunol. 14: 1308807. PMID: 38259466
  11. 人类 cyr61 基因的染色体图谱和在神经系统肿瘤细胞中的表达。  |  Martinerie, C., et al. 1997. Mol Pathol. 50: 310-6. PMID: 9536281
  12. CYR61 是生长因子诱导型即时早期基因的产物,能促进血管生成和肿瘤生长。  |  Babic, AM., et al. 1998. Proc Natl Acad Sci U S A. 95: 6355-60. PMID: 9600969

订购信息

产品名称产品编号规格价格数量收藏夹

Cyr61/CCN1 抗体 (A-10)

sc-374129
200 µg/ml
$316.00

Cyr61/CCN1 (A-10): m-IgG Fc BP-HRP 套装

sc-527437
200 µg Ab; 10 µg BP
$354.00

Cyr61/CCN1 (A-10): m-IgG1 BP-HRP 套装

sc-532810
200 µg Ab; 20 µg BP
$354.00

Cyr61/CCN1 抗体 (A-10) AC

sc-374129 AC
500 µg/ml, 25% agarose
$416.00

Cyr61/CCN1 抗体 (A-10) HRP

sc-374129 HRP
200 µg/ml
$316.00

Cyr61/CCN1 抗体 (A-10) FITC

sc-374129 FITC
200 µg/ml
$330.00

Cyr61/CCN1 抗体 (A-10) PE

sc-374129 PE
200 µg/ml
$343.00

Cyr61/CCN1 抗体 (A-10) Alexa Fluor® 488

sc-374129 AF488
200 µg/ml
$357.00

Cyr61/CCN1 抗体 (A-10) Alexa Fluor® 546

sc-374129 AF546
200 µg/ml
$357.00

Cyr61/CCN1 抗体 (A-10) Alexa Fluor® 594

sc-374129 AF594
200 µg/ml
$357.00

Cyr61/CCN1 抗体 (A-10) Alexa Fluor® 647

sc-374129 AF647
200 µg/ml
$357.00

Cyr61/CCN1 抗体 (A-10) Alexa Fluor® 680

sc-374129 AF680
200 µg/ml
$357.00

Cyr61/CCN1 抗体 (A-10) Alexa Fluor® 790

sc-374129 AF790
200 µg/ml
$357.00

What is the immunogen for this antibody?

Asked by: Jackson167
Thank you for your question. Cyr61 Antibody (A-10): sc-374129 has been raised against amino acids 163-240 of Cyr61 of human origin.
Answered by: Tech Support Europe
Date published: 2019-08-26

Can Cyr61 (A-10): sc-374129 be used to probe for protein isolated from mice on western blot?

Asked by: WesternAddict
Thank you for your question. We haven’t yet tested this antibody in mouse samples and so that is not a recommended species at this time.
Answered by: Technical Support
Date published: 2019-04-13

Can Cyr61 (A-10): sc-374129 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Cweed
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, Cyr61 (A-10): sc-374129 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
  • y_2025, m_8, d_27, h_5CST
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Rated 4 out of 5 by from works well for overexpressorWorks great for overexpressor sample but not been tested for endogenous protein.
Date published: 2017-11-18
Rated 5 out of 5 by from Great antibodyGreat antibody for WB, IHCP and IF. Cyr61 Antibody (A-10) produced specific results in these applications
Date published: 2017-01-25
Rated 4 out of 5 by from Worked well with transfected lysate by WBWorked well with transfected lysate by WB -SCBT QC
Date published: 2015-05-19
Rated 4 out of 5 by from Nice band seen in WB using MDANice band seen in WB using MDA-MB-231 whole cell lysate. -SCBT QC
Date published: 2015-02-23
Rated 5 out of 5 by from Exceptional immunofluorescence extracellularExceptional immunofluorescence extracellular staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-01-15
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Cyr61/CCN1抗体 (A-10) is rated 4.4 out of 5 by 5.
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