Date published: 2026-10-17
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connexin 43 Antibody (CXN-6) - Immunofluorescence - Image 142924
connexin 43 抗体 (CXN-6): sc-59949. 甲醇固定的 HeLa 细胞免疫荧光染色, 显示膜定位.
connexin 43 Antibody (CXN-6) - Immunofluorescence - Image 142924
connexin 43 抗体 (CXN-6): sc-59949. 甲醇固定的 HeLa 细胞免疫荧光染色, 显示膜定位.
connexin 43 Antibody (CXN-6) - Western Blotting - Image 41768
connexin 43 抗体 (CXN-6): sc-59949. 未转染: sc-117752 (A) 和转染: sc-119391 (B) 的 293T 全细胞裂解液和小鼠脑组织提取物 (C) 中连接蛋白 43 表达的 Western 印迹分析.
connexin 43 Antibody (CXN-6) - Western Blotting - Image 55778
connexin 43 抗体 (CXN-6): sc-59949. 大鼠小脑 (A) 和小鼠小脑 (B) 组织提取物中连接蛋白 43 表达的 Western 印迹分析.
connexin 43 抗体 (CXN-6): sc-59949. 甲醇固定的 HeLa 细胞免疫荧光染色, 显示膜定位.

connexin 43 抗体 (CXN-6): sc-59949

4.1(8)
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说明书
  • connexin 43 抗体 CXN-6 是小鼠单克隆 IgM, 在38篇文献中引用，提供 100 µl ascites
  • 免疫human物种的connexin 43的氨基酸362-381
  • 推荐用于 mouse, rat, human 和 bovine 来源的connexin 43 WB, IP, IF 和 IHC(P)检测
  • 看 connexin 43 (F-7): sc-271837，可查看有标记的 connexin 43 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前，我们还没有完成connexin 43 抗体 (CXN-6)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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関連項目

额外Connexin抗体，包括connexin 26, connexin 30, connexin 30.3, connexin 31, connexin 31.1, connexin 32, connexin 36, connexin 40, connexin 43, connexin 45, connexin 46, connexin 47和connexin 50

connexin 43抗体（CXN-6）是一种IgM小鼠单克隆connexin 43抗体（也称为connexin 43抗体或GJA1抗体），可通过WB、IP、IF和IHC(P)检测小鼠、大鼠和人类来源的connexin 43。connexin 43抗体（CXN-6）可作为非偶联抗connexin 43抗体。连接蛋白是一组形成六聚体以构成连接子的间隙连接蛋白。连接子簇形成间隙连接，通过该连接，低分子量蛋白质可以从细胞扩散到细胞。具有恶性表型的几种哺乳动物细胞表现出连接蛋白表达和间隙连接通讯的减少。在Src转化的细胞中，间隙连接通讯减少，这似乎与connexin 43的酪氨酸磷酸化有关。活化的c-Src在Tyr 265上磷酸化connexin 43的C端尾部，导致两种蛋白之间的稳定相互作用，从而导致间隙连接通讯的抑制。除了酪氨酸磷酸化外，还已显示在没有Src激酶的情况下，connexin 43在丝氨酸上被磷酸化，并且在表达Src激酶的细胞（如c-Src和/或pp60v-Src）中，connexin 43在丝氨酸和酪氨酸上都被磷酸化。在人类血管内皮细胞中，connexin 43在有丝分裂期间发生翻译后修饰。connexin 43的有丝分裂特异性磷酸化与间隙连接细胞间通讯的短暂丧失和connexin 43的重新分布相关。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

connexin 43 抗体 (CXN-6) 参考文献:

  1. 在缺血/再灌注损伤、心脏保护和神经保护方面，连接蛋白43是一个新兴的治疗靶点。  |  Schulz, R., et al. 2015. Pharmacol Ther. 153: 90-106. PMID: 26073311
  2. 连接蛋白43在心血管疾病中的作用。  |  Michela, P., et al. 2015. Eur J Pharmacol. 768: 71-6. PMID: 26499977
  3. 在脓毒症期间，依赖连接蛋白43的ATP释放介导巨噬细胞活化。  |  Dosch, M., et al. 2019. Elife. 8: PMID: 30735126
  4. 胶质母细胞瘤-星形胶质细胞连接素43间隙连接促进肿瘤侵袭  |  McCutcheon, S. and Spray, DC. 2022. Mol Cancer Res. 20: 319-331. PMID: 34654721
  5. 连接蛋白43通过激活PI3K产生耐药性。  |  Pridham, KJ., et al. 2022. Oncogenesis. 11: 2. PMID: 35022385
  6. 连接蛋白 43 半通道调控成骨细胞向骨细胞的分化  |  Hua, R., et al. 2022. Front Cell Dev Biol. 10: 892229. PMID: 35693933
  7. 心脏功能和疾病中PKC对丝氨酸-368的连接蛋白43磷酸化作用。  |  Pun, R., et al. 2022. Front Cardiovasc Med. 9: 1080131. PMID: 36712244
  8. 星形胶质细胞连接蛋白43调节海马突触的突触囊泡释放。  |  Cheung, G., et al. 2023. Cells. 12: PMID: 37190042
  9. 连接蛋白43介导的集体细胞迁移与高尔基定位无关。  |  Sharma, M., et al. 2023. Biol Open. 12: PMID: 37815438
  10. 病毒感染中连接蛋白43的调节。  |  Scott, H., et al. 2024. Tumour Virus Res. 18: 200296. PMID: 39522757

订购信息

产品名称产品编号规格价格数量收藏夹

connexin 43 抗体 (CXN-6)

sc-59949
100 µl ascites
$322.00

Do you have bulk production for this antibody if so what is the price? connexin 43 Antibody (CXN-6): sc-59949

Asked by: Stela
Thank you for your question. Please contact our technical service team with your requirements for this antibody for a quote.
Answered by: Tech Support Europe
Date published: 2024-03-28

What is the concentration of connexin 43 (CXN-6): sc-59949?

Asked by: jenniferc
Unfortunately, we do not characterize the concentration of antibody when provided as an ascites. Antibodies are provided in ascites fluid with 0.1% sodium azide.
Answered by: Technical Support 15
Date published: 2017-01-24

What secondary reagent should I use for the connexin 43 Antibody (CXN-6) in Western blot applications?

Asked by: Trav11
We recommend using one of our exclusive Mouse IgG Binding Proteins as a secondary detection reagent, such as m-IgGκ BP-HRP: sc-516102, for Western blot. A complete list of all available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Tech Service 8
Date published: 2016-12-19

I would like to use the connexin 43 Antibody (CXN-6) for Western blot in canine samples. Is this possible?

Asked by: Trav11
For additional species reactivity inquiries, please contact our Technical Service department at 800-457-3801 and we will be more than happy to run sequence analysis for your species of interest.
Answered by: Tech Service 8
Date published: 2016-12-19
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Rated 5 out of 5 by cjMara from Popular choice for connexin 43The CXN-6 clone is an IgM antibody that is a very popular choice for IF and IHC applications; currently featured in over a dozen journal articles.
Date published: 2016-12-29
Rated 4 out of 5 by LR from Publishable data in IHC using human tumorPublishable data in IHC using human tumor cell lines. -SCBT Publication Review
Date published: 2015-05-08
Rated 4 out of 5 by QZ from Publishable data in IF using human mesenchymalPublishable data in IF using human mesenchymal stem cells. -SCBT Publication Review
Date published: 2015-04-20
Rated 4 out of 5 by TO from Good immunofluorescence membrane stainingGood immunofluorescence membrane staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-04-19
Rated 4 out of 5 by JM from Worked with transfected lysate by WBWorked with transfected lysate by WB -SCBT QC
Date published: 2015-04-07
Rated 4 out of 5 by TO from Publishable data in ICC using human achillesPublishable data in ICC using human achilles tendons. -SCBT Publication Review
Date published: 2015-03-12
Rated 4 out of 5 by JL from Robust bands detected in WB using rat cerebellumRobust bands detected in WB using rat cerebellum and mouse cerebellum tissue extracts. -SCBT QC
Date published: 2015-03-10
Rated 4 out of 5 by MS from Publishable data in WB using mouse 3Y1Publishable data in WB using mouse 3Y1, SR3Y1, S17N Ras SR cell lines. -SCBT Publication Review
Date published: 2015-01-15
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connexin 43 抗体 (CXN-6) is rated 4.1 out of 5 by 8.
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