Clodronate, Disodium Salt CAS: 22560-50-5
MF: CH2Cl2O6P2Na2
MW: 288.86
A bisphosphonate apoptosis inducing agent.

Clodronate, Disodium Salt (CAS 22560-50-5)

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同义词: Clasteon; Clodronic acid disodium salt; Loron
应用; A bisphosphonate apoptosis inducing agent
CAS号码: 22560-50-5
纯度: ≥98%
分子量: 288.86
分子式: CH2Cl2O6P2Na2
* 参考分析证明 大量特定数据 (包括水 含量).
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Clodronate, Disodium Salt is a first-generation bisphosphonate which are synthetic compounds characterized by a P-C-P bond. Experiments have shown that the P-C-P bond of the bisphosphonates is completely resistant to enzymatic hydrolysis. This compound has been reported to inhibit bone resorption and can be metabolized intracellularly to a β,γ-methylene analog of ATP, which in vitro is cytotoxic to macrophages. Additionally, Clodronate demonstrates the ability to cause a collapse of the mitochondrial membrane potential which eventually results in osteoclast apoptosis.


参考文献

1. Fleisch, H.A. 1997. Ann. Med. 29: 55-62. PMID: 9073324
2. Lipton, A. 1997. Cancer. 80: 1668-1673. PMID: 9362434
3. Virtanen, S.S., et al. 2002. Cancer Res. 62: 2708-2714. PMID: 11980672
4. Lehenkari, P.P., et al. 2002. Mol. Pharmacol. 61: 1255-1262. PMID: 11961144
5. Traeger, T., et al. 2010. Eur J Gastroenterol Hepatol. 22: 1039-1049. PMID: 20300005

物理状态 :
Solid
溶解度 :
Soluble in water.
保存 :
Store at room temperature
IC50 :
PC-3 prostate cancer cells: IC50 = 100 nM
仅供科研使用。不可用于诊断或治疗。
RTECS :
SZ7640700
PubChem CID :
31195
默克索引 :
14: 2371
MDL 号码 :
MFCD01632786
EC号码 :
245-078-9
SMILES :
C(P(=O)(O)[O-])(P(=O)(O)[O-])(Cl)Cl.[Na+].[Na+]

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PMID: # 27816795  Wallner, FK. et al. 2017. Cytokine. 90: 73-79.

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