CinnGEL 2-methylester MF: C25H34N4O8
MW: 518.60
A cell-permeable PTP1B inhibitor.

CinnGEL 2-methylester

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应用; CinnGEL 2-methylester is a cell-permeable PTP1B inhibitor
纯度: ≥98%
分子量: 518.60
分子式: C25H34N4O8
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

CinnGEL 2Me is a cell-permeable protein tyrosine phosphatase-1B (PTP1B) inhibitor. PTP1B negatively regulates EGF-induced signaling and its inhibition reduces both Src kinase activity and colony formation of colon cancer cells. Research shows that PTP1B has the ability to suppress cell cycle entry.


参考文献

1. Zhu, S., et al. 2007. Cancer Res. 67: 10129-10137. PMID: 17974954
2. Harris, D.L. and Joyce, N.C. 2007. Mol. Vis. 13: 785-796. PMID: 17563729
3. Ishino, Y., et al. 2008. Mol. Vis. 14: 61-70. PMID: 18253097

物理状态 :
Solid
溶解度 :
Soluble in DMSO, and ethanol.
保存 :
Store at -20° C
IC50 :
PTP1B: IC50 = 1.3 µM
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
SMILES :
CC(C)C[[email protected]@H](C(=O)N)NC(=O)[C[email protected]](CCC(=O)OC)NC(=O)CNC(=O)C1=CC=C(C=C1)/C=C/C(=O)OC

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PMID: # 25668475  Chamorro, ME. et al. 2015. Int. J. Biochem. Cell Biol. 61: 63-71.

PMID: # 22903352  Vota, DM. et al. 2013. Cell biochemistry and biophysics. 65: 145-57.

PMID: # 31831727  Nat Commun. 10: 5686.

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