Chromomycin A3 CAS: 7059-24-7
MF: C57H82O26
MW: 1183.25
A G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye.

Chromomycin A3 (CAS 7059-24-7)

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应用; A G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye
CAS号码: 7059-24-7
纯度: ≥97%
分子量: 1183.25
分子式: C57H82O26
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* 参考分析证明 大量特定数据 (包括水 含量).
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Chromomycin A3, a fluorescent DNA stain and antibiotic, has been reported to strongly inhibit zinc-dependent transcriptional activity of sheep Metallothionein 1A promoter in reporter gene assays of transfected cells. This compound has also been shown to be a potent inhibitor of neuronal apoptosis induced by glutathione depletion-induced oxidative stress and DNA-damaging agent Camptothecin (sc-200871). Mechanistic studies suggest that Chromomycin A3 antagonizes enhanced DNA binding of the transcription factors Sp1 and Sp3 to their cognate "G-C" box, induced by oxidative stress or DNA damage. Furthermore, by inhibiting transcription, Chromomycin A3 and its structural analogs can inhibit protein biosynthesis.


参考文献

1. Jeon, C.J., et al. 1993. J. Histochem. Cytochem. 41: 1651-1658. PMID: 8409373
2. Wong, S.S., et al. 1994. Biochem. Pharmacol. 47: 827-837. PMID: 7510966
3. Chatterjee, S., et al. 2001. Ann. Neurol. 49: 345-354. PMID: 11261509
4. Mir, M.A., et al. 2003. Bioorg. Med. Chem. 11: 2791-2801. PMID: 12788353
5. Hoyos, P., et al. 2010. Acc. Chem. Res. 43: 288-299. PMID: 19908854

物理状态 :
Solid
来源于 :
Streptomyces griseus
溶解度 :
Soluble in ethanol, DMSO, and ethyl acetate (10 mg/ml).
保存 :
Store at -20° C
熔点 :
185° C (dec.)
折射率 :
n20D 1.62
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
GB7875000
PubChem CID :
5179132
默克索引 :
14: 2238
MDL 号码 :
MFCD00043151
EC号码 :
230-348-0
SMILES :
CC1C(C(CC(O1)OC2C(CC3=C(C2=O)C(=C4C(=C3)C=C(C(=C4O)C)OC5CC(C(C(O5)C)OC(=O)C)OC6CC(C(C(O6)C)OC)O)O)C(C(=O)C(C(C)O)O)OC)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)OC(=O)C)(C)O)O

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