CGS 35066 CAS: 261619-50-5
CGS 35066 is a potent endothelin-converting enzyme (ECE) inhibitor.

CGS 35066 (CAS 261619-50-5)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 132ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
备用名: α-[(S)-(Phosphonomethyl)amino]-3-dibenzofuranpropanoic acid
应用; CGS 35066 is a potent endothelin-converting enzyme (ECE) inhibitor
CAS号码: 261619-50-5
纯度: >98%
分子量: 349.28
分子式: C16H16NO6P
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

CGS 35066 is a a potent endothelin-converting enzyme (ECE) inhibitor. When compared to neutral endopeptidase 24.11, it displays > 100-fold selectivity (IC50 values are 22 and 2300 nM respectively). Another interesting property of CGS 35066 is that it blocks the hypertensive effects induced by big ET-1 n vitro and is able to reduce the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH).


参考文献

De Lombaert et al (2000) Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action. J.Med.Chem. 43 488. Trapani et al (2000) Pharmacological properties of CGS 35066, a potent and selective endothelin-

物理状态 :
Solid
溶解度 :
Soluble in 1eq. NaOH (100 mM).
保存 :
Desiccate at room temperature
熔点 :
304.03° C (Predicted)
沸点 :
~638.89° C at 760 mmHg (Predicted)
密度 :
~1.5 g/cm3 (Predicted)
折射率 :
n20D 1.70 (Predicted)
IC50 :
neutral endopeptidase 24: IC50 = 22 nM; neutral endopeptidase 11: IC50 = 3300 nM; Endothelin-converting enzyme 1: IC50 = 22 nM (human); Neprilysin: IC50 = 2300 nM (human); Neprilysin: IC50 = 2300 nM (Rattus norvegicus)
pK值 :
pKa: 0.79, pKb: 10.58
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
MDL 号码 :
MFCD09971085
SMILES :
C1=CC=C2C(=C1)C3=C(O2)C=C(C=C3)C[[email protected]@H](C(=O)O)NCP(=O)(O)O

下载SDS

分析证明书

在PDF文件上阅读,打印和批注,Adobe阅读器是必须的

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 119ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 6ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

圣克鲁斯生物技术在生物医药研究市场的产品开发方面处于世界领先地位。欢迎 致电我们的免费电话(021) 800-820-8626。 版权 ©, 2007-2021圣克鲁斯生物技术。版权所有。“Santa Cruz Biotechnology”,圣克鲁斯生物技 术的 商标,“Santa Cruz Animal Health”,“San Juan Ranch”,“Supplement of Champions”,San Juan Ranch的商标,“Ultracruz”,“Chemcruz”,“Immunocruz”,“Exactacruz”和“EZ Touch”都是圣克鲁斯生物技术的注册商标。所有的商标都归其各自拥有者所有。