Date published: 2025-9-5
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CGRP Antibody (4901) - Western Blotting - Image 323550
CGRP 抗体 (4901): sc-57053. 大鼠睾丸 (A) 和大鼠附睾 (B) 组织提取物中 CGRP 表达的 Western 印迹分析.
CGRP 抗体 (4901): sc-57053. 大鼠睾丸 (A) 和大鼠附睾 (B) 组织提取物中 CGRP 表达的 Western 印迹分析.

CGRP 抗体 (4901): sc-57053

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说明书
  • CGRP 抗体 4901 是小鼠单克隆 IgG1 κ，CGRP抗体, 在57篇文献中引用，规格为200 µg/ml
  • 免疫rat物种的CGRP1
  • CGRP 抗体 (4901) 推荐用于 WB, IP, IF 和 ELISA，检测mouse, rat, human 和canine 来源的 CGRP1 and CGRP2
  • 抗CGRP抗体（4901）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 另提供生物素偶联抗体，可用于WB、IHC(P)和ELISA实验
  • 关于如何获取CGRP (4901): sc-57053的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP和 1 BP-HRP">m-IgG1 BP-HRP是CGRP Antibody (4901) for WB applications. 的首选辅助检测试剂，这些试剂现与CGRP Antibody (4901) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

附加CGRP抗体，包括CGRP-RCP

CGRP抗体（4901）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和酶联免疫吸附测定（ELISA）等方法检测小鼠、大鼠、人类和犬类样本中的CGRP。CGRP (4901) 抗体有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 结合物。降钙素基因相关肽（CGRP）是一种由37个氨基酸组成的神经肽，在血管舒张和疼痛通路调节中起着至关重要的作用，因此CGRP在偏头痛和其他血管疾病中具有重要意义。CGRP（4901）单克隆抗体主要检测中枢和周围神经系统中的这种神经肽，CGRP在这些系统中由感觉神经元合成并释放。CGRP在这些部位的含量对于调节神经源性炎症和调节血流至关重要，尤其是在偏头痛等CGRP水平通常升高的疾病中。CGRP基因CALCA通过选择性剪接产生不同的同工型，包括CGRP1和CGRP2，它们具有不同的生物学活性。了解CGRP的定位和功能对于开发偏头痛和其他相关疾病的靶向疗法至关重要，这凸显了抗CGRP抗体（4901）在研究和临床应用中的重要性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CGRP 抗体 (4901) 参考文献:

  1. 降钙素对卵巢切除大鼠骨骼的影响  |  Wronski, TJ., et al. 1991. Endocrinology. 129: 2246-50. PMID: 1915104
  2. 第二个人类降钙素/CGRP 基因位于第 11 号染色体上。  |  Höppener, JW., et al. 1985. Hum Genet. 70: 259-63. PMID: 2991116
  3. 在大脑中表达一种编码与降钙素基因相关肽同源的新型神经肽的信使核糖核酸。  |  Amara, SG., et al. 1985. Science. 229: 1094-7. PMID: 2994212
  4. 降钙素基因相关肽（CGRP）：在偏头痛病理生理学和治疗靶向中的作用。  |  Wattiez, AS., et al. 2020. Expert Opin Ther Targets. 24: 91-100. PMID: 32003253
  5. 新型抗偏头痛药物--Lasmiditan、Gepants和降钙素基因相关肽（CGRP）受体单克隆抗体的药代动力学、药效学和药物相互作用。  |  Szkutnik-Fiedler, D. 2020. Pharmaceutics. 12: PMID: 33287305
  6. 抑郁症和抗降钙素基因相关肽（CGRP）（配体或受体）抗体治疗偏头痛。  |  de Vries Lentsch, S., et al. 2024. Eur J Neurol. 31: e16106. PMID: 37847221
  7. 人类前降钙素的完整序列。  |  Le Moullec, JM., et al. 1984. FEBS Lett. 167: 93-7. PMID: 6546550
  8. 降钙素基因在体内的调控。  |  Silver, J. and Naveh-Many, T. 1993. Horm Metab Res. 25: 470-2. PMID: 8225199
  9. 人类降钙素/CGRP/IAPP 基因家族成员的高分辨率染色体定位。  |  Hoovers, JM., et al. 1993. Genomics. 15: 525-9. PMID: 8468047
  10. 降钙素 mRNA 在肝脏中通过两种不同的剪接途径产生。  |  Bracq, S., et al. 1997. Mol Cell Endocrinol. 128: 111-5. PMID: 9140082
  11. 淀粉样蛋白, 降钙素基因相关肽, 降钙素和肾上腺髓质素：一个肽超家族。  |  Wimalawansa, SJ. 1997. Crit Rev Neurobiol. 11: 167-239. PMID: 9209829
  12. 替代 RNA 处理--它在调节降钙素/降钙素基因相关肽表达中的作用。  |  Lou, H. and Gagel, RF. 1998. J Endocrinol. 156: 401-5. PMID: 9582495

订购信息

产品名称产品编号规格价格数量收藏夹

CGRP 抗体 (4901)

sc-57053
200 µg/ml
$316.00

CGRP (4901): m-IgG Fc BP-HRP 套装

sc-526893
200 µg Ab; 10 µg BP
$354.00

CGRP (4901): m-IgG1 BP-HRP 套装

sc-532266
200 µg Ab; 20 µg BP
$354.00

CGRP 抗体 (4901) AC

sc-57053 AC
500 µg/ml, 25% agarose
$416.00

CGRP 抗体 (4901) HRP

sc-57053 HRP
200 µg/ml
$316.00

CGRP 抗体 (4901) FITC

sc-57053 FITC
200 µg/ml
$330.00

CGRP 抗体 (4901) PE

sc-57053 PE
200 µg/ml
$343.00

CGRP 抗体 (4901) Alexa Fluor® 488

sc-57053 AF488
200 µg/ml
$357.00

CGRP 抗体 (4901) Alexa Fluor® 546

sc-57053 AF546
200 µg/ml
$357.00

CGRP 抗体 (4901) Alexa Fluor® 594

sc-57053 AF594
200 µg/ml
$357.00

CGRP 抗体 (4901) Alexa Fluor® 647

sc-57053 AF647
200 µg/ml
$357.00

CGRP 抗体 (4901) Alexa Fluor® 680

sc-57053 AF680
200 µg/ml
$357.00

CGRP 抗体 (4901) Alexa Fluor® 790

sc-57053 AF790
200 µg/ml
$357.00

CGRP 抗体 (4901) B

sc-57053 B
200 µg/ml
$320.00

I want to know if the CGRP Antibody (4901), could be used for the detection of CGRP in human saliva in a study on migraine in patients with neurocysticercosis?

Asked by: Bettsy57
Thank you for your question. This antibody has not been tested on human saliva, but it is recommended for detection of CGRP1 and CGRP2 of mouse, rat, human and canine origin, independent of cell type, by WB, IP, IF and ELISA.
Answered by: Tech Support Europe
Date published: 2022-02-04

Hi, I am looking for an antibody for human CGRP peptide to be used in western blot, and that would not cross-react with procalcitonin and calcitonin. Which antibody would be best? Thanks, svetlana

Asked by: sreilly
Thank you for your question. Our antibody sc-57053, is specific for CGRP1 and CGRP2, and should not detect calcitonin.
Answered by: Tech Service
Date published: 2019-09-26

I want to know the size of CGRP in. CGRP Antibody (4901): sc-57053

Asked by: qingyuan li
Thank you for your question. The expected molecular weight of the pro-form of CGRP is approximately 17 kDa, and the active form is approximately 4 kDa.
Answered by: Technical Support
Date published: 2019-04-13

Why the band of CGRP in WB occurs at near 19kDa in your figure while the molecular weight of CGRP is only around 3.5kDa?

Asked by: Violet_du
Thank you for your question. The active form of this protein is ~4kDa while the pro form (proCGRP) is ~17-19 kDa. Either form can be detected depending on what is present in the cells. Please contact technical service if you need further assistance.
Answered by: Tech Service
Date published: 2019-03-13

I would like to try a sample of this mouse anti-CGRP antibody, please

Asked by: BrianM
Thank you for your question. We would be happy to send you a sample of this antibody, sc-57053. Please contact Technical Service by phone, (800)-457-3801 option 2, email <scbt@scbt.com>, or by live chat directly on our website, www.scbt.com, and we would be happy to send you a sample.
Answered by: Tech Service
Date published: 2021-01-19

I need to use an antibody to detect the protein in samples of bovine origin. Do you know if this mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Tech Service 3
Date published: 2017-01-27
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Rated 5 out of 5 by from GreatIt works well for IF with dialution of 1:100 in human paraffin section.
Date published: 2023-04-26
Rated 4 out of 5 by from IF on mouse lungs works fineImmunofluorescence staining on mouse lungs works ok with this ab.
Date published: 2018-09-19
Rated 5 out of 5 by from Good productionWe tested the product on protein lysis of rat primary microglia. The result presented a good band.
Date published: 2018-03-01
Rated 5 out of 5 by from goodIt works well for IF with dialution of 1:100-1:200 in frozen rat TNC.
Date published: 2017-09-10
Rated 4 out of 5 by from WorksImmunofluorescence in frozen mice spinal cord slices with 1:100 sample antibody. Did not compare with other company, but the distribution of positive cells seems in the right layer.
Date published: 2017-06-25
Rated 4 out of 5 by from Good antibody for mouse stainingIHC on mouse worked really well, human ICC didn't work at all.
Date published: 2017-06-14
Rated 5 out of 5 by from Produced publishable IF data on rat and humanWell characterized in the primary literature with a handful of publications on rat samples in IF.
Date published: 2017-01-10
Rated 5 out of 5 by from Great antibodyWe used this CGRP antibody in past 10 years in our research, and never failed.
Date published: 2016-11-19
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CGRP 抗体 (4901) is rated 4.6 out of 5 by 12.
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