Molecular structure of Cdk9 Inhibitor II, CAS Number: 140651-18-9
Cdk9 Inhibitor II (CAS 140651-18-9)
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Alternate Names:
4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol; CAN508
Application:
Cdk9 Inhibitor II is an ATP-competitive inhibitor of Cdk9 and moderate inhibitor of similar enzymes
CAS Number:
140651-18-9
Purity:
≥95%
Molecular Weight:
218.2
Molecular Formula:
C9H10N6O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cdk9 Inhibitor II is an ATP-competitive inhibitor of cyclin-dependent kinase 9 (Cdk9 IC50 = 350 nM) and moderate inhibitor of similar enzymes including Cdk2-cyclin E. In the HT-29 cancer cell line, Cdk9 inhibitor II was observed to attenuate the frequency of the S-phase. Other Cdk9 Inhibitor II effects were shown to involve inhibition of mRNA synthesis, induction of p53, inhibition of IL-6 signaling and reduced phosphorylation of both retinoblastoma protein and RNA polymerase II at the C-terminal domain. Cdk9 Inhibitor II has been observed to be an effective antitumor and antimetastatic agent by disrupting TNFalpha signaling. Cdk9 Inhibitor II is an inhibitor of Cdk4, cyclin D1 and p70 S6 Kinase.
Cdk9 Inhibitor II (CAS 140651-18-9) References
- Cyclin-dependent kinase 9 is required for tumor necrosis factor-alpha-stimulated matrix metalloproteinase-9 expression in human lung adenocarcinoma cells. | Shan, B., et al. 2005. J Biol Chem. 280: 1103-11. PMID: 15528190
- 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. | Krystof, V., et al. 2006. J Med Chem. 49: 6500-9. PMID: 17064068
- Direct inhibition of CDK9 blocks HIV-1 replication without preventing T-cell activation in primary human peripheral blood lymphocytes. | Salerno, D., et al. 2007. Gene. 405: 65-78. PMID: 17949927
- The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression. | Hou, T., et al. 2007. J Biol Chem. 282: 37091-102. PMID: 17956865
- Development and applications of a broad-coverage, TR-FRET-based kinase binding assay platform. | Lebakken, CS., et al. 2009. J Biomol Screen. 14: 924-35. PMID: 19564447
- CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing. | Pirngruber, J., et al. 2009. EMBO Rep. 10: 894-900. PMID: 19575011
- Adenovirus L-E1A activates transcription through mediator complex-dependent recruitment of the super elongation complex. | Vijayalingam, S. and Chinnadurai, G. 2013. J Virol. 87: 3425-34. PMID: 23302885
- P-TEFb Kinase Activity Is Essential for Global Transcription, Resumption of Meiosis and Embryonic Genome Activation in Pig. | Oqani, RK., et al. 2016. PLoS One. 11: e0152254. PMID: 27011207
- RNA polymerase II pausing modulates hematopoietic stem cell emergence in zebrafish. | Yang, Q., et al. 2016. Blood. 128: 1701-10. PMID: 27520065
- Antitumor effects of cyclin dependent kinase 9 inhibition in esophageal adenocarcinoma. | Tong, Z., et al. 2017. Oncotarget. 8: 28696-28710. PMID: 28404924
- Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis. | Castrogiovanni, C., et al. 2018. Cell Death Differ. 25: 190-203. PMID: 28937686
- Positive transcription elongation factor b (P-TEFb) is a therapeutic target in human multiple myeloma. | Zhang, Y., et al. 2017. Oncotarget. 8: 59476-59491. PMID: 28938651
- Transcription Elongation Factor P-TEFb Is Involved in IL-17F Signaling in Airway Smooth Muscle Cells. | Nakajima, M., et al. 2018. Int Arch Allergy Immunol. 176: 83-90. PMID: 29649811
- Nuclear Progestin Receptor Phosphorylation by Cdk9 Is Required for the Expression of Mmp15, a Protease Indispensable for Ovulation in Medaka. | Ogiwara, K. and Takahashi, T. 2019. Cells. 8: PMID: 30836650
Inhibitor of:
CaMKI, CaMKIV, Cdk4, Cdk9, ChoK, cyclin δ-1, p70 S6 Kinase, and PCTAIRE-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cdk9 Inhibitor II, 5 mg | sc-203326 | 5 mg | $172.00 |