Date published: 2025-9-7

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CCK-BR 抗体 (E-3): sc-166690

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说明书
  • CCK-BR 抗体 E-3 是小鼠单克隆 IgG1 κ,CCK-BR抗体, 在9篇文献中引用,规格为200 µg/ml
  • 针对氨基酸1-85的抗原,在CCK-BR的N-terminus处映射,human来源
  • CCK-BR 抗体 (E-3) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse, rat 和human 来源的 CCK-BR
  • 抗CCK-BR抗体(E-3)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取CCK-BR (E-3): sc-166690免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 CCK-BR 抗体 (E-3) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与CCK-BR 抗体 (E-3) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

CCK-BR抗体(E-3)是一种IgG1κ小鼠单克隆CCK-BR抗体(也称为CCK-BR抗体),可通过WB、IP、IF、IHC(P)和ELISA等方法检测小鼠、大鼠和人体来源的CCK-BR蛋白。CCK-BR抗体(E-3)既可以是非偶联的抗CCK-BR抗体形式,也可以是多种偶联形式的抗CCK-BR抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。胃泌素负责刺激各种消化功能。在胃泌素的作用下,胃粘膜产生并分泌盐酸,而胰腺则分泌消化酶。胃泌素还刺激平滑肌收缩,增加胃和肠道的血液循环和水分泌。在大脑中,胆囊收缩素(CCK)是一种神经递质,参与饱腹感、应激和焦虑的调节。CCK在胃肠道(GI)系统和中枢神经系统(CNS)中均有表达,这进一步证明CCK可调节食物摄入。CCK和胃泌素均通过两种G蛋白偶联受体--CCK-AR和CCK-BR来介导其效应。CCK优先以高亲和力结合CCK-AR,而CCK-BR则以几乎相等的亲和力结合胃泌素和CCK。胆囊收缩素受体及其配体是GI或CNS疾病潜在的治疗靶点。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CCK-BR 抗体 (E-3) 参考文献:

  1. 介导胃泌素促进生长效应的信号通路。  |  Yassin, RR. 1999. Peptides. 20: 885-98. PMID: 10477091
  2. 胆囊收缩素受体配体的治疗和化学发展。  |  de Tullio, P., et al. 2000. Expert Opin Investig Drugs. 9: 129-46. PMID: 11060666
  3. 胆囊收缩素在可卡因渴求中的参与:胆囊收缩素受体配体的作用。  |  Crespi, F., et al. 2000. Expert Opin Investig Drugs. 9: 2249-58. PMID: 11060804
  4. 胃泌素抗细胞凋亡作用的分子机制。  |  Todisco, A., et al. 2001. Am J Physiol Gastrointest Liver Physiol. 280: G298-307. PMID: 11208554
  5. 洛西格鲁米是一种CCK-A受体颉颃物,能刺激人体的卡路里摄入量和饥饿感。  |  Beglinger, C., et al. 2001. Am J Physiol Regul Integr Comp Physiol. 280: R1149-54. PMID: 11247838
  6. 帕金森病中的胆囊收缩素、胆囊收缩素-A受体和胆囊收缩素-B受体基因多态性。  |  Wang, J., et al. 2003. Pharmacogenetics. 13: 365-9. PMID: 12777967
  7. 小脑、前额叶皮层和扣带回中的胆囊收缩素-B受体基因表达及其与自杀的关系。  |  Sherrin, T., et al. 2004. Neurosci Lett. 357: 107-10. PMID: 15036586
  8. 前列腺细胞上的胃泌素/胆囊收缩素-B受体--双功能前列腺癌成像的新靶点。  |  Sturzu, A., et al. 2014. Eur J Pharm Sci. 52: 69-76. PMID: 24211650
  9. 一种针对胰腺导管腺癌的胆囊收缩素B受体特异性DNA适配子。  |  Clawson, GA., et al. 2017. Nucleic Acid Ther. 27: 23-35. PMID: 27754762
  10. 肠促胃泌素/CCKBR(胆囊收缩素B受体)通过PKC(蛋白激酶C)介导的NHERF1和NHERF2途径抑制肠Na+/H+交换酶3活性,从而改善盐敏感型高血压。  |  Jiang, X., et al. 2022. Hypertension. 79: 1668-1679. PMID: 35674015
  11. 小鼠胃泌素基因的分子克隆和测序。  |  Koh, TJ. and Wang, TC. 1995. Biochem Biophys Res Commun. 216: 34-41. PMID: 7488110
  12. 胆囊收缩素-B受体拮抗剂CI-988未能影响CCK-4引起的恐慌症患者症状。  |  van Megen, HJ., et al. 1997. Psychopharmacology (Berl). 129: 243-8. PMID: 9084062

订购信息

产品名称产品编号规格价格数量收藏夹

CCK-BR 抗体 (E-3)

sc-166690
200 µg/ml
$316.00

CCK-BR (E-3): m-IgG Fc BP-HRP 套装

sc-529031
200 µg Ab; 10 µg BP
$354.00

CCK-BR (E-3): m-IgGκ BP-HRP 套装

sc-521711
200 µg Ab, 40 µg BP
$354.00

CCK-BR (E-3): m-IgG1 BP-HRP 套装

sc-543279
200 µg Ab; 20 µg BP
$354.00

CCK-BR 抗体 (E-3) AC

sc-166690 AC
500 µg/ml, 25% agarose
$416.00

CCK-BR 抗体 (E-3) HRP

sc-166690 HRP
200 µg/ml
$316.00

CCK-BR 抗体 (E-3) FITC

sc-166690 FITC
200 µg/ml
$330.00

CCK-BR 抗体 (E-3) PE

sc-166690 PE
200 µg/ml
$343.00

CCK-BR 抗体 (E-3) Alexa Fluor® 488

sc-166690 AF488
200 µg/ml
$357.00

CCK-BR 抗体 (E-3) Alexa Fluor® 546

sc-166690 AF546
200 µg/ml
$357.00

CCK-BR 抗体 (E-3) Alexa Fluor® 594

sc-166690 AF594
200 µg/ml
$357.00

CCK-BR 抗体 (E-3) Alexa Fluor® 647

sc-166690 AF647
200 µg/ml
$357.00

CCK-BR 抗体 (E-3) Alexa Fluor® 680

sc-166690 AF680
200 µg/ml
$357.00

CCK-BR 抗体 (E-3) Alexa Fluor® 790

sc-166690 AF790
200 µg/ml
$357.00

抗体保质期怎么查看

Asked by: zhang
Thank you for your inquiry. Please contact our Technical Service Department. Our Asian Technical Service team is available at (+86) 021-60936350 or asia@scbio.cn or by live chat on our website. 感谢您的提问。请联系我们的技术支持部门。亚洲技术支持电话(+86) 021-60936350、邮箱asia@scbio.cn、或选择网页上Live Chat中的“中文支持”。
Answered by: Yanru Tao
Date published: 2024-08-19

What is the recommended fixation method for immunofluorescence staining with CCK-BR (E-3): sc-166690 monoclonal antibody?

Asked by: Cweed
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10°C methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-02-24
  • y_2025, m_8, d_27, h_5CST
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Rated 5 out of 5 by from Successful application of this antibody in IFSuccessful application of this antibody in IF, using human tissues.
Date published: 2017-09-17
Rated 5 out of 5 by from Reliable Antibody Great for IP/WBThis antibody is well-cited for a variety of applications including WB, IP, IF, and even ELISA. Strong, clear signal with little to no background. Works well in a variety of species including mouse, rat, and human samples.
Date published: 2017-01-27
Rated 5 out of 5 by from Excellent immunofluorescence cytoplasmicExcellent immunofluorescence cytoplasmic staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-05-06
Rated 5 out of 5 by from Great Western Blot data of CCKGreat Western Blot data of CCK-BR expression in SK-N-MC, IMR-32 and H4 whole cell lysates and mouse brain and rat heart tissue extracts. -SCBT QC
Date published: 2013-12-10
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CCK-BR 抗体 (E-3) is rated 5.0 out of 5 by 4.
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