Caspase-1 inhibitor VI
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Caspase-1 inhibitor VI also known as Z-YVAD-FMK is a cell-permeable, irreversible inhibitor of caspase-1, caspase-4, and caspase-5 activity. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Active caspase-1, a (p20/p10)2 tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. Following use of the inhibitor, standard apoptosis assays can be used to examine treated cells for evidence of apoptosis.Additional caspase-1 inhibitors available:Caspase-1 inhibitor (sc-3069)Caspase-1 Inhibitor II (sc-300323)Caspase-1 Inhibitor IV (sc-300324)Caspase-1 Inhibitor I (sc-358878)
Caspase-1 inhibitor VI References
- Fas/CD95/Apo-I activates the acidic sphingomyelinase via caspases. | Brenner, B., et al. 1998. Cell Death Differ. 5: 29-37. PMID: 10200443
- A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. | Thornberry, NA., et al. 1992. Nature. 356: 768-74. PMID: 1574116
- Ex vivo assessment of chemotherapy-induced apoptosis and associated molecular changes in patient tumor samples. | Pirnia, F., et al. 2006. Anticancer Res. 26: 1765-72. PMID: 16827105
- Innate immune recognition of Yersinia pseudotuberculosis type III secretion. | Auerbuch, V., et al. 2009. PLoS Pathog. 5: e1000686. PMID: 19997504
- Involvement of an ICE-like protease in Fas-mediated apoptosis. | Enari, M., et al. 1995. Nature. 375: 78-81. PMID: 7536900
- Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer. | Walker, NP., et al. 1994. Cell. 78: 343-52. PMID: 8044845
- CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis. | Schlegel, J., et al. 1996. J Biol Chem. 271: 1841-4. PMID: 8567626
- Caspases: enemies within. | Thornberry, NA. and Lazebnik, Y. 1998. Science. 281: 1312-6. PMID: 9721091
- Inhibition of human caspases by peptide-based and macromolecular inhibitors. | Garcia-Calvo, M., et al. 1998. J Biol Chem. 273: 32608-13. PMID: 9829999
- Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB. | Hilbi, H., et al. 1998. J Biol Chem. 273: 32895-900. PMID: 9830039
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Caspase-1 inhibitor VI, 500 µg | sc-3071 | 500 µg | $186.00 | |||
Caspase-1 inhibitor VI, 1 mg | sc-3071A | 1 mg | $582.00 |