CalciFluor™ Fluo-8, AM (CAS 1345980-40-6)
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CalciFluor™ Fluo-8, AM has been developed to improve cell loading and calcium response while maintaining the convenient Fluo-3 and Fluo-4 spectral wavelength of maximum excitation at ~490 nm and maximum emission at ~520 nm. Similarly to Fluo 4 AM, the anionic carboxy groups are protected with acetoxy methyl esters allowing membrane permeability, which are subsequently removed by intracellular esterases allowing Ca2+ detection. CalciFluor™ Fluo-8, AM is efficiently loaded into cells at room temperature, whereas Fluo-3 and Fluo-4 require much harsher loading conditions. It is also two times brighter than Fluo-4 and four times brighter than Fluo-3. These features, as well as a lower price, make CalciFluor™ Fluo-8, AM a superior in vivo calcium indicator.
CalciFluor™ Fluo-8, AM (CAS 1345980-40-6) References
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- Dimethyl fumarate alters intracellular Ca2+ handling in immune cells by redox-mediated pleiotropic effects. | Herrmann, AK., et al. 2019. Free Radic Biol Med. 141: 338-347. PMID: 31279969
- HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells. | Datta, G., et al. 2019. Front Cell Neurosci. 13: 329. PMID: 31379513
- Piezo1 channel activation in response to mechanobiological acoustic radiation force in osteoblastic cells. | Zhang, G., et al. 2021. Bone Res. 9: 16. PMID: 33692342
- Magnetic field-induced Ca2+ intake by mesenchymal stem cells is mediated by intracellular Zn2+ and accompanied by a Zn2+ influx. | Özgün, A. and Garipcan, B. 2021. Biochim Biophys Acta Mol Cell Res. 1868: 119062. PMID: 34033861
- Protoplast: A Valuable Toolbox to Investigate Plant Stress Perception and Response. | Gilliard, G., et al. 2021. Front Plant Sci. 12: 749581. PMID: 34675954
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CalciFluor™ Fluo-8, AM, 1 mg | sc-362561 | 1 mg | $306.00 |