Date published: 2025-9-6

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Cacna2d1 抗体 (E-10): sc-271697

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说明书
  • Cacna2d1 抗体 E-10 是小鼠单克隆 IgG1 κ,Cacna2d1抗体, 在12篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列25-171位于human物种的Cacna2d1的N-terminus附近
  • Cacna2d1 抗体 (E-10) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse, rat 和human 来源的 Cacna2d1
  • 抗Cacna2d1抗体(E-10)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Cacna2d1 (E-10): sc-271697免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 Cacna2d1 抗体 (E-10) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Cacna2d1 抗体 (E-10) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

Cacna2d1抗体(E-10)是一种IgG1 κ小鼠单克隆Cacna2d1抗体(也称为Cacna2d1抗体),可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人类的Cacna2d1蛋白。Cacna2d1抗体(E-10)既可以是非偶联的抗Cacna2d1抗体形式,也可以是多种偶联形式的抗Cacna2d1抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。电压依赖性钙通道对于神经递质的释放至关重要。Cacna2d1(钙通道,电压依赖性,α2/δ亚基1),也称为CACNA2、CCHL2A、MHS3或CACNL2A,是一种包含1091个氨基酸的单次跨膜I型膜蛋白,含有一个VWFA结构域和一个cache结构域。Cacna2d1在骨骼肌、主动脉组织和中枢神经系统(CNS)中表达,作为电压依赖性钙通道的α-2/δ亚基发挥作用,并在钙电流密度以及兴奋-收缩耦联中起重要作用。Cacna2d1前体经过蛋白水解加工产生两个功能亚基,称为α-2-1和δ-1,它们之间通过二硫键相互连接。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cacna2d1 抗体 (E-10) 参考文献:

  1. 人类α(2)/δ钙通道亚基基因(CACNA2)的基因组结构和功能表达。  |  Schleithoff, L., et al. 1999. Genomics. 61: 201-9. PMID: 10534405
  2. 一种新型人类神经元钙通道亚型的 alpha 1, alpha 2 和 beta 亚基的结构和功能表达。  |  Williams, ME., et al. 1992. Neuron. 8: 71-84. PMID: 1309651
  3. 有几个结构域有助于调节 N 型钙通道的 beta 3 亚基失活。  |  Stotz, SC., et al. 2004. J Biol Chem. 279: 3793-800. PMID: 14602720
  4. 促进 Cav2.1(P/Q 型)通道的基本机制。  |  Chaudhuri, D., et al. 2007. J Gen Physiol. 129: 385-401. PMID: 17438119
  5. 编码 DHP 敏感钙通道 alpha 1 和 alpha 2 亚基的 mRNA 的序列和表达。  |  Ellis, SB., et al. 1988. Science. 241: 1661-4. PMID: 2458626
  6. 系统遗传学确定了Cacna2d1在眼压升高和青光眼易感性中的作用。  |  Chintalapudi, SR., et al. 2017. Nat Commun. 8: 1755. PMID: 29176626
  7. 钙电压门控通道辅助亚基(CACNA2D1)缺失对小鼠眼压的影响。  |  Lankford, L., et al. 2024. Exp Eye Res. 241: 109835. PMID: 38373629
  8. 运动训练通过下调CACNA2D1蛋白来影响钙离子转运,从而减轻高血压对小鼠心肌的损伤。  |  Gao, S., et al. 2024. iScience. 27: 109351. PMID: 38495825
  9. CACNA2D1调节结肠癌的进展并影响其微环境。  |  Inoue, H., et al. 2024. J Gastroenterol. 59: 556-571. PMID: 38536483
  10. 将编码 L 型电压依赖性钙通道 alpha 2/delta 亚基的基因定位到 7q 染色体,并分析恶性高热症易感家族中侧翼标记的分离情况。  |  Iles, DE., et al. 1994. Hum Mol Genet. 3: 969-75. PMID: 7951247
  11. 人类神经元电压依赖性钙通道:亚基结构和通道组装作用研究。  |  Brust, PF., et al. 1993. Neuropharmacology. 32: 1089-102. PMID: 8107964
  12. 通过体细胞杂交分析将编码人类骨骼肌电压依赖性 Ca2+ 通道 alpha 2/delta 亚基 (CACNL2A) 的基因定位到染色体 7q21-q22 上。  |  Powers, PA., et al. 1994. Genomics. 19: 192-3. PMID: 8188232

订购信息

产品名称产品编号规格价格数量收藏夹

Cacna2d1 抗体 (E-10)

sc-271697
200 µg/ml
$316.00

Cacna2d1 (E-10): m-IgG Fc BP-HRP 套装

sc-529244
200 µg Ab; 10 µg BP
$354.00

Cacna2d1 (E-10): m-IgGκ BP-HRP 套装

sc-522029
200 µg Ab, 40 µg BP
$354.00

Cacna2d1 (E-10): m-IgG1 BP-HRP 套装

sc-543410
200 µg Ab; 20 µg BP
$354.00

Cacna2d1 抗体 (E-10) AC

sc-271697 AC
500 µg/ml, 25% agarose
$416.00

Cacna2d1 抗体 (E-10) HRP

sc-271697 HRP
200 µg/ml
$316.00

Cacna2d1 抗体 (E-10) FITC

sc-271697 FITC
200 µg/ml
$330.00

Cacna2d1 抗体 (E-10) PE

sc-271697 PE
200 µg/ml
$343.00

Cacna2d1 抗体 (E-10) Alexa Fluor® 488

sc-271697 AF488
200 µg/ml
$357.00

Cacna2d1 抗体 (E-10) Alexa Fluor® 546

sc-271697 AF546
200 µg/ml
$357.00

Cacna2d1 抗体 (E-10) Alexa Fluor® 594

sc-271697 AF594
200 µg/ml
$357.00

Cacna2d1 抗体 (E-10) Alexa Fluor® 647

sc-271697 AF647
200 µg/ml
$357.00

Cacna2d1 抗体 (E-10) Alexa Fluor® 680

sc-271697 AF680
200 µg/ml
$357.00

Cacna2d1 抗体 (E-10) Alexa Fluor® 790

sc-271697 AF790
200 µg/ml
$357.00

Is the product in stock? How long is the delivery time?

Asked by: Valarie93
Thank you for your question. Please contact our Customer Care Department for current product availability.
Answered by: Technical Support
Date published: 2019-02-01

Could you send me a FREE 10 µg sample of Cacna2d1 (E-10): sc-271697 ? I want to see if it works for immunoprecipitation. Thanks.

Asked by: HL Pan
Thank you for your question. Please contact Technical Service for more information on how to receive a 10 μg sample of our well characterized monoclonal antibody.
Answered by: Technical Support
Date published: 2018-12-05

Are there any issues with using sc-271697: Cacna2d1 (E-10) mouse monoclonal primary antibody on mouse samples?

Asked by: Dr Ninau Qelp
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-271697 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 5 out of 5 by from Detection was successful by WB.We transfected CHO-K1 cells with a CACNA2D1 expression construct and performed WB. The background noise was low and the sensitivity was sufficient.
Date published: 2024-11-28
Rated 5 out of 5 by from Worked well as a membrane protein markerWorked well for western blotting as a membrane protein marker. I used for detecting protein from MCF-7 proteins.
Date published: 2019-01-02
Rated 5 out of 5 by from Great monoclonal antibodyCacna2d1 Antibody (E-10) produced nice, clear and strong results by Western blot
Date published: 2017-01-26
Rated 5 out of 5 by from Great Western Blot data of Cacna2d1 expressionGreat Western Blot data of Cacna2d1 expression in HeLa whole cell lysate. -SCBT QC
Date published: 2015-01-13
Rated 5 out of 5 by from Produced positive Western Blot data of Cacna2d1Produced positive Western Blot data of Cacna2d1 expression in mouse brain and human skeletal muscle tissue extracts. -SCBT QC
Date published: 2013-01-30
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Cacna2d1 抗体 (E-10) is rated 5.0 out of 5 by 5.
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