Date published: 2026-10-19

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C/EBP beta 抗体 (47A1): sc-56637

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  • C/EBP beta 抗体 47A1 是小鼠单克隆 IgG1, 在11篇文献中引用,提供 50 µg/0.5 ml
  • 免疫human物种的C/EBP β的氨基酸1-271
  • 推荐用于 mouse, rat 和 human 来源的C/EBP β WB 和 IP检测
  • 看 C/EBP beta (H-7): sc-7962,可查看有标记的 C/EBP beta 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前,我们还没有完成C/EBP beta 抗体 (47A1)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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C/EBP β抗体(47A1)是一种小鼠单克隆IgG1抗体,可通过蛋白质印迹(WB)和免疫沉淀(IP)等方法检测小鼠、大鼠和人类样本中的C/EBP β。C/EBP β 是一种重要的转录因子,属于 CCAAT 增强子结合蛋白家族,在多种细胞类型的分化中发挥着重要作用,包括肝脏、脂肪组织、血细胞和内分泌胰腺。C/EBP β 尤其重要,因为它参与调节肝细胞的急性期反应,而急性期反应是人体对炎症和损伤作出反应的关键过程。C/EBP β以多种异构体形式存在,通过在多个AUG起始位点进行可变翻译起始而产生,从而实现多种功能。C/EBP β的磷酸化对于DNA结合能力至关重要,而与Stat3的相互作用对于白细胞介素6介导的C/EBP β基因转录也至关重要,从而将C/EBP β与肝细胞的急性期反应直接联系起来。急性期反应期间C/EBP β同源物的上调和结构改变增强了结合亲和力,凸显了C/EBP β在细胞应激和炎症反应中的动态作用。抗C/EBP β抗体(47A1)是研究人员研究这些关键生物过程的宝贵工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

C/EBP beta 抗体 (47A1) 参考文献:

  1. C/EBP β在LPS刺激的人牙周韧带细胞中介导内质网应激调节的炎症反应和细胞外基质降解。  |  Yang, HN., et al. 2011. Biomaterials. 32: 5924-33. PMID: 21600648
  2. 非人灵长类动物模型在选择性孕激素受体调节剂(SPRM)的发现和临床开发中的作用。  |  Rui, W., et al. 2013. Mol Biol Rep. 40: 797-801. PMID: 23065276
  3. 在活化的小胶质细胞中,IL-13 对 C/EBP-α 和 C/EBP-β 的相互调节可防止神经元死亡。  |  Pan, HC., et al. 2013. Eur J Immunol. 43: 2854-65. PMID: 23881867
  4. PRMT7缺乏通过调节C/EBP-β促进脂肪生成。  |  Bai, Y., et al. 2016. Int J Mol Sci. 17: 385. PMID: 27011164
  5. 表皮生长因子受体和C/EBP-β致癌信号在人类胶质瘤中是双向的,并随C/EBP-β异构体的变化而变化。  |  Selagea, L., et al. 2016. FASEB J. 30: 4098-4108. PMID: 27572958
  6. C/EBP-β受 PPARα 激动剂非诺贝特酸和 GW7647 的不同影响,但不会改变 ER 应激和炎症过程中载脂蛋白 A-I 的产生。  |  van der Krieken, SE., et al. 2017. J Cell Biochem. 118: 754-763. PMID: 27618583
  7. 孕酮受体:生殖组织中的多种形式和功能。  |  Feng, Y., et al. 2019. Sleep Breath. 23: 953-962. PMID: 30680681
  8. 雌激素受体α和孕激素受体A和B在足月分娩时子宫下段的浓度和定位。  |  Leem, YE., et al. 2019. Biochem Biophys Res Commun. 517: 484-490. PMID: 31371025
  9. C/EBP-β通过在植入过程中靶向细胞重塑基因,促进猪子宫内膜LE的受精。  |  Sun, Y., et al. 2022. Reproduction. 164: 269-281. PMID: 36099329
  10. 抑制Caspase-8活性可提高小鼠雄性生殖干细胞的冷冻效率。  |  Maejima, Y., et al. 2024. Nat Commun. 15: 6279. PMID: 39060225

订购信息

产品名称产品编号规格价格数量收藏夹

C/EBP beta 抗体 (47A1)

sc-56637
50 µg/0.5 ml
$322.00

I'm trying to find an antibody that detects both the Lap and Lap* isoforms, but NOT Lip. Can you tell me all the isoforms detected by C/EBP β Antibody (47A1)? Can you recomend an IF/ICC antibody that only detects the Lap/Lap* isoforms? Thanks

Asked by: Glory
Thank you for your question. Please contact your local distributor or technical service for further assistance.
Answered by: Tech Service 1
Date published: 2024-06-04

I am using C/EBP β (47A1): sc-56637 antibody for immunoprecipitation, how much antibody should I use?

Asked by: Trav11
Thank you for your question. We recommend using 1–10 µl (i.e., 0.2–2 µg) of antibody with 1 ml of cell lysate. However, optimal antibody concentration should be determined by titration. Please find our full immunoprecipitation protocol here: https://www.scbt.com/scbt/resources/protocols/immunoprecipitation-western-blots
Answered by: Technical Support
Date published: 2017-03-24
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Rated 4 out of 5 by MS from Worked well for WB with Jurkat whole cell lysatesWorked well for WB with Jurkat whole cell lysates. -SCBT QC
Date published: 2015-04-28
Rated 4 out of 5 by TS from Great WB data in HeLa and Hep G2 nuclear extractsGreat WB data in HeLa and Hep G2 nuclear extracts. -SCBT QC
Date published: 2013-06-21
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C/EBP beta 抗体 (47A1) is rated 4.3 out of 5 by 3.
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