BMS 195614 CAS: 253310-42-8
MF: C29H24N2O3
MW: 448.51
A neutral RARα (retinoic acid receptor α) inhibitor.

BMS 195614 (CAS 253310-42-8)

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备用名: BMS614
应用; BMS 195614 is a neutral RARα (retinoic acid receptor α) inhibitor
CAS号码: 253310-42-8
纯度: ≥97%
分子量: 448.51
分子式: C29H24N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

BMS 195614 is a selective neutral RARα inhibitor and exhibits no significant effect on NCoR binding. The compound potentially decreases agonist-induced coactivator recruitment and SMRT binding to RAR. RARs, or Retinoic Acid Receptors, are nuclear hormone receptors that form heterodimers with RXRs (Retinoid X Receptors).

物理状态 :
Solid
溶解度 :
Soluble in DMSO (25 mM).
保存 :
Store at -20° C
熔点 :
300.64° C (Predicted)
沸点 :
607.26° C at 760 mmHg (Predicted)
密度 :
1.29 g/cm3 (Predicted)
折射率 :
n20D 1.69 (Predicted)
Ki 数据 :
Neutral retinoic acid receptor α: Ki= 2.5 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
445091
MDL 号码 :
MFCD00952209
SMILES :
CC1(CC=C(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)C4=CC5=CC=CC=C5N=C4)C

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