Bimatoprost CAS: 155206-00-1
MF: C25H37NO4
MW: 415.57
The precursor to a potent PGFR agonist.

Bimatoprost (CAS 155206-00-1)

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备用名: Lumigan
应用; Bimatoprost is the precursor to a potent PGFR agonist
CAS号码: 155206-00-1
纯度: ≥94%
分子量: 415.57
分子式: C25H37NO4
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

Bimatoprost is converted by an amidase enzymatic activity in bovine and human cornea models to yield the corresponding free acid, 17-phenyl trinor PGF, a potent PGFR agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.


参考文献

1. Balapure, A K., et al., 1989. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2 alpha receptor. Implications for development of a photoaffinity probe. Biochemical pharmacology. 38(14): 2375-81. PMID: 2751699
2. Lake, S., et al., 1994. Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor. FEBS letters. 355(3): 317-25. PMID: 7988697
3. Woodward, D F., et al., 2001. The pharmacology of bimatoprost (Lumigan). Survey of ophthalmology. 45 Suppl 4(): S337-45. PMID: 11434936
4. Maxey, Kirk M., et al., 2002. The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist. Survey of ophthalmology. 47 Suppl 1(): S34-40. PMID: 12204699

外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in ethanol (~50 mg/ml), methanol, DMSO (~25 mg/ml), DMF (~25 mg/ml), and PBS (pH 7.2) (~300 ug/ml).
保存 :
Store at -20° C
熔点 :
66-68° C
沸点 :
~629.8° C at 760 mmHg (Predicted)
密度 :
~1.1 g/cm3 (Predicted)
折射率 :
n20D 1.59
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
5311027
默克索引 :
14: 1221
MDL 号码 :
MFCD03411999
SMILES :
CCNC(=O)CCC/C=C\\C[[email protected]]1[[email protected]](C[[email protected]]([[email protected]@H]1/C=C/[[email protected]](CCC2=CC=CC=C2)O)O)O

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引用1 - 11

PMID: # 27552406  Kam, WR. et al. 2016. Invest. Ophthalmol. Vis. Sci. 57: 4287-94.

引用1 - 11
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