β-taxilin Antibody (A-5): sc-377287
- β-taxilin Antibody (A-5) is a mouse monoclonal IgG1 κ β-taxilin antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 495-529 near the C-terminus of β-taxilin of human origin
- beta-taxilin Antibody (A-5) is recommended for detection of β-taxilin of human origin by WB, IP, IF and ELISA
- Anti-beta-taxilin Antibody (A-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for β-taxilin Antibody (A-5) for WB applications. These reagents are now offered in bundles with β-taxilin Antibody (A-5) (see ordering information below).
β-taxilin Antibody (A-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects β-taxilin of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). β-taxilin Antibody (A-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. β-taxilin, also known as MDP77, plays a crucial role in promoting nerve regeneration and is implicated in intracellular vesicle transport, which is vital for maintaining cellular communication and function. Predominantly expressed in cardiac and skeletal muscle, β-taxilin interacts with syntaxin family members STX1A, STX3A, and STX4A through its coiled coil region, facilitating essential processes in neurotransmitter release and muscle contraction. Additionally, β- and γ-taxilins bind to the alpha subunit of the nascent polypeptide-associated complex (NAC), influencing nuclear distribution and suggesting that the taxilin family is integral not only to the translational process via NAC interaction but also to transcriptional regulation through alphaNAC association. This multifaceted role underscores β-taxilin′s importance in both neuronal and muscular systems, making anti-β-taxilin antibody (A-5) a valuable tool for researchers studying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
β-taxilin Antibody (A-5) References:
- MDP77: A novel neurite-outgrowth-promoting protein predominantly expressed in chick muscles. | Uyeda, A., et al. 2000. Biochem Biophys Res Commun. 269: 564-9. PMID: 10708594
- Regulatory expression of MDP77 protein in the skeletal and cardiac muscles. | Fujimori, KE., et al. 2002. FEBS Lett. 529: 303-8. PMID: 12372618
- Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells. | Nogami, S., et al. 2003. Genes Cells. 8: 17-28. PMID: 12558796
- Interaction of taxilin with syntaxin which does not form the SNARE complex. | Nogami, S., et al. 2003. Biochem Biophys Res Commun. 311: 797-802. PMID: 14623251
- Muscle-specific protein MDP77 specifically promotes motor nerve regeneration in rats. | Itoh, S., et al. 2004. Neurosci Lett. 360: 175-7. PMID: 15082161
- Identification and characterization of taxilin isoforms. | Nogami, S., et al. 2004. Biochem Biophys Res Commun. 319: 936-43. PMID: 15184072
- Interaction of the taxilin family with the nascent polypeptide-associated complex that is involved in the transcriptional and translational processes. | Yoshida, K., et al. 2005. Genes Cells. 10: 465-76. PMID: 15836775
- Estrogen modulation of hypothalamic neurons: activation of multiple signaling pathways and gene expression changes. | Malyala, A., et al. 2005. Steroids. 70: 397-406. PMID: 15862823
- Long-term effects of muscle-derived protein with molecular mass of 77 kDa (MDP77) on nerve regeneration. | Itoh, S., et al. 2005. J Neurosci Res. 81: 730-8. PMID: 16007679
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β-taxilin Antibody (A-5) | sc-377287 | 200 µg/ml | $322.00 | |||
β-taxilin Antibody (A-5): m-IgG Fc BP-HRP Bundle | sc-530003 | 200 µg Ab; 10 µg BP | $361.00 | |||
β-taxilin Antibody (A-5): m-IgGκ BP-HRP Bundle | sc-523267 | 200 µg Ab, 40 µg BP | $361.00 | |||
β-taxilin Antibody (A-5): m-IgG1 BP-HRP Bundle | sc-543813 | 200 µg Ab; 20 µg BP | $361.00 | |||
β-taxilin Antibody (A-5) AC | sc-377287 AC | 500 µg/ml, 25% agarose | $424.00 | |||
β-taxilin Antibody (A-5) HRP | sc-377287 HRP | 200 µg/ml | $322.00 | |||
β-taxilin Antibody (A-5) FITC | sc-377287 FITC | 200 µg/ml | $336.00 | |||
β-taxilin Antibody (A-5) PE | sc-377287 PE | 200 µg/ml | $349.00 | |||
β-taxilin Antibody (A-5) Alexa Fluor® 488 | sc-377287 AF488 | 200 µg/ml | $364.00 | |||
β-taxilin Antibody (A-5) Alexa Fluor® 546 | sc-377287 AF546 | 200 µg/ml | $364.00 | |||
β-taxilin Antibody (A-5) Alexa Fluor® 594 | sc-377287 AF594 | 200 µg/ml | $364.00 | |||
β-taxilin Antibody (A-5) Alexa Fluor® 647 | sc-377287 AF647 | 200 µg/ml | $364.00 | |||
β-taxilin Antibody (A-5) Alexa Fluor® 680 | sc-377287 AF680 | 200 µg/ml | $364.00 | |||
β-taxilin Antibody (A-5) Alexa Fluor® 790 | sc-377287 AF790 | 200 µg/ml | $364.00 | |||
β-taxilin (A-5) Neutralizing Peptide | sc-377287 P | 100 µg/0.5 ml | $69.00 |