Date published: 2026-10-16

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beta Arrestin 1/2 抗体 (21-B1): sc-53781

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  • beta Arrestin 1/2 抗体 21-B1 是小鼠单克隆 IgG1, 在5篇文献中引用,提供 200 µg/ml
  • 针对β-arrestin 1,来自human来源
  • 推荐用于 mouse, rat 和 human 来源的β-Arrestin 1 and β-Arrestin 2 WB, IP 和 IHC(P)检测
  • 看 β-Arrestin-2 (B-4): sc-365445,可查看有标记的 beta Arrestin 1/2 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前,我们还没有完成beta Arrestin 1/2 抗体 (21-B1)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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β-Arrestin-1/2 抗体 (21-B1) 是一种小鼠单克隆 IgG1 抗体,可检测小鼠、大鼠、人和牛等多个物种的 β-Arrestin-1 和 β-Arrestin-2 。抗β-阿restin-1/2 抗体(21-B1)是针对与人β-阿restin-1 的丝氨酸 86 至苏氨酸 98 周围区域相对应的合成肽提出的,可用于免疫印迹(WB)、免疫沉淀(IP)和石蜡包埋切片免疫组织化学(IHCP)等应用的检测。β-Arrestin 蛋白是 G 蛋白偶联受体(GPCR)信号传导的关键调节因子,在介导受体脱敏和内化的同时,还能启动独立于 G 蛋白的替代信号传导途径。从结构上看,β-阿restin-1 和 β-Arrestin-2 均由两个不同的结构域组成:一个 N 端结构域和一个 C 端结构域,这两个结构域共同形成一个双叶结构,对于它们与磷酸化 GPCR 和各种信号蛋白的相互作用至关重要。翻译后修饰,包括磷酸化和泛素化,通过调节细胞内的相互作用、稳定性和定位,在调节 β-Arrestins 的功能方面起着至关重要的作用。这些修饰对于精确控制受体贩运和信号终止至关重要,从而影响激素信号转导、神经传递和免疫反应等多种生理过程。β-阿restin-1和β-阿restin-2主要在脾脏和神经元组织中表达,是维持细胞平衡和促进对细胞外刺激做出适当反应不可或缺的成分。此外,β-阿restin 与各种激酶和适配蛋白相互作用,进一步强调了它们在细胞内信号网络中的重要性。β-阿restin-1/2(21-B1)单克隆抗体性能稳定可靠,是研究人员研究β-阿restin 介导的信号通路的结构和功能动态的宝贵工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

beta Arrestin 1/2 抗体 (21-B1) 参考文献:

  1. 吗啡对大鼠脑中β-arrestin 1和β-arrestin 2基因表达的差异调节。  |  Fan, XL., et al. 2003. Neuroscience. 117: 383-9. PMID: 12614678
  2. β-Arrestins调节腺病毒载体诱导的先天免疫反应:β-arrestin-1和β-arrestin-2的差异调节。  |  Seregin, SS., et al. 2010. Virus Res. 147: 123-34. PMID: 19896992
  3. β-arrestin-1和β-arrestin-2在调节人类肥大细胞C3a受体信号传导方面发挥独特和共同的作用。  |  Vibhuti, A., et al. 2011. PLoS One. 6: e19585. PMID: 21589858
  4. 在抑郁症小鼠模型中,精神分裂症中断-1 Gln31Leu 多态性会导致社交失调,而社交失调与单胺类物质失衡, CREB和β-arrestin-1,2在脑核中的减少有关。  |  Lipina, TV., et al. 2013. Neuropsychopharmacology. 38: 423-36. PMID: 23011268
  5. β-arrestin 1 和 β-arrestin 2 在 ORG27569 诱导的大麻素受体 1(CB1)偏向信号传导和内化过程中的不同作用。  |  Ahn, KH., et al. 2013. J Biol Chem. 288: 9790-9800. PMID: 23449980
  6. 小鼠对LSD的反应需要β-arrestin 2,但不需要β-arrestin 1。  |  Rodriguiz, RM., et al. 2021. Sci Rep. 11: 17690. PMID: 34480046
  7. 妊娠期糖尿病患者血清中β-arrestin-1和β-arrestin-2浓度降低。  |  Oğlak, SC., et al. 2022. J Matern Fetal Neonatal Med. 35: 10017-10024. PMID: 35674413
  8. β-arrestin-1和β-arrestin-2抑制MRGPRX2引发的人类皮肤肥大细胞脱颗粒和ERK1/2激活。  |  Wang, Z., et al. 2022. Front Allergy. 3: 930233. PMID: 35910860
  9. 胰高血糖素样肽-1受体胞外表面残基在β-arrestin 1/2信号传导中的独特作用。  |  Lei, S., et al. 2024. Eur J Pharmacol. 968: 176419. PMID: 38360293
  10. 神经激肽-1受体(NK1-R)在神经元中的脱敏:物质P对NK1-R、伽马q/11、G蛋白受体激酶-2/3和β-arrestin-1/2分布的影响。  |  McConalogue, K., et al. 1998. Mol Biol Cell. 9: 2305-24. PMID: 9693383

订购信息

产品名称产品编号规格价格数量收藏夹

beta Arrestin 1/2 抗体 (21-B1)

sc-53781
200 µg/ml
$322.00

Hi, do you know the epitope recognized by this Ab?

Asked by: qsdfsfqsdf
Thank you for your question. sc-53781 was raised against the full length raised against β-arrestin 1 of human origin. The exact epitope was not mapped yet.
Answered by: Tech Support Europe
Date published: 2021-12-16

I am using β-Arrestin-1/2 (21-B1): sc-53781 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: Trav11
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by Randy McDonald from Nice western blot resultsWe used this antibody for a western blot experiment and got nice dark bands at the correct molecular weight
Date published: 2017-01-19
Rated 4 out of 5 by AB from Clear band obtained by Western Blot in SupT1Clear band obtained by Western Blot in SupT1-L23 cell line and in CD4+ lymphocytes
Date published: 2015-10-21
Rated 4 out of 5 by QZ from Published IP data with human HeLa and HEKPublished IP data with human HeLa and HEK 293 cells - SCBT Publication Review
Date published: 2015-04-02
Rated 4 out of 5 by ET from DecentDecent, clear band detected in WB in PC-12, SK-N-MC and RAW 264.7 whole cell lysates. -SCBT QC
Date published: 2015-02-28
Rated 4 out of 5 by HC from Produced robust immunoperoxidase cytoplasmicProduced robust immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human cerebellum tissue. -SCBT QC
Date published: 2013-06-01
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beta Arrestin 1/2 抗体 (21-B1) is rated 4.2 out of 5 by 5.
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