B-Cell Immunosuppressant

物理状态 :

Solid

溶解度 :

Soluble in DMSO (25 mg/ml), and methanol (5 mg/ml).

保存 :

Store at 4° C

IC50 :

kinase activities of EGFR: IC₅₀ = >30 µM; kinase activities of PDGFR: IC₅₀ = >30 µM; kinase activities of Cdk2: IC₅₀ = >30 µM; kinase activities of Src: IC₅₀ = >30 µM; Ab formation: IC₅₀ = 300 nM (trinitrophenyl-lipopolysaccharide (TNP-LPS) B-cells); T-cell immunosuppressive activity: IC₅₀ = 22.4 µM (mouse mixed lymphocyte reaction); Jurkat cell proliferation: IC₅₀ = 50 µM

pK值 :

pK_a: 10.47 (Predicted), pK_b: 3.13 (Predicted)

PubChem CID :

SMILES :

C1=CC2=C(C(=C1)C(=O)NC3=NC=C(C=C3)C(F)(F)F)N=CC=C2