Avarol CAS: 55303-98-5
MF: C21H30O2
MW: 314.5
A cytostatic agent which has potent antileukemic activity.

Avarol (CAS 55303-98-5)

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应用; A cytostatic agent which has potent antileukemic activity
CAS号码: 55303-98-5
纯度: ≥97%
分子量: 314.5
分子式: C21H30O2
* 参考分析证明 大量特定数据 (包括水 含量).
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Avarol is a cytostatic agent which has potent antileukemic activity in vitro and. Avarol also displays antibacterial and antifungal activities against a limited range of microorganisms. Inhibits HIV-1 reverse transcriptase. Avarol is an inhibitor of Cox, group II sPLA2 and LO.


参考文献

1. Kurelec, B., et al. 1985. Mutat. Res. 144: 63-66. PMID: 3900707
2. Muller, W.E., et al. 1985. Cancer Res. 45: 4822-4826. PMID: 3839712
3. Muller, W.E., et al. 1986. Eur. J. Cancer Clin. Oncol. 22: 473-476. PMID: 3488220
4. Sarin, P.S., et al. 1987. J. Natl. Cancer Inst. 78: 663-666. PMID: 2435942
5. Schroder, H.C., et al. 1989. Cancer Res. 49: 2069-2076. PMID: 2495175
6. Loya, S. and Hizi, A. 1990. FEBS Lett. 269: 131-134. PMID: 1696911
7. Belisario, M.A., et al. 1992. Toxicology. 72: 221-233. PMID: 1566281
8. Ferrandiz, M.L., et al. 1994. Eur. J. Pharmacol. 253: 75-82. PMID: 8013550
9. Belisario, M.A., et al. 1996. Pharmacol. Toxicol. 79: 300-304. PMID: 9000256
10. Amigo, M., et al. 2004. J. Nat. Prod. 67: 1459-1463. PMID: 15387642
11. Muller, W.E., et al. 2004. Mar. Biotechnol. 6: 105-117. PMID: 15085406
12. Tsoukatou, M., et al. 2007. Molecules. 12: 1022-1034. PMID: 17873837

物理状态 :
Solid
来源于 :
marine sponge Dysidea avara
溶解度 :
Soluble in ethanol, and DMSO.
保存 :
Store at -20° C
熔点 :
175.22° C (Predicted)
沸点 :
449.49° C at 760 mmHg (Predicted)
密度 :
1.06 g/cm3 (Predicted)
折射率 :
n20D 1.55 (Predicted)
IC50 :
Cox-2: IC50 = 2.3 µM (human); PBMC: IC50 = 3 µM (human); P388: IC50 = 3.1 µM (mouse); HT-29: IC50 = 6 µM (human); A549: IC50 = 6 µM (human)
pK值 :
pKa: 10.74 (Predicted)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
72185
MDL 号码 :
MFCD01657132
SMILES :

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