Date published: 2025-9-6
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ATF3 Antibody (44C3a) - Western Blotting - Image 16552
ATF-3 抗体 (44C3a): sc-81189 对人重组 ATF-3 融合蛋白进行 Western 印迹分析.
ATF3 Antibody (44C3a) - Western Blotting - Image 16552
ATF-3 抗体 (44C3a): sc-81189 对人重组 ATF-3 融合蛋白进行 Western 印迹分析.
ATF3 Antibody (44C3a) - Western Blotting - Image 393606
ATF-3 抗体 (44C3a): sc-81189. 未转染 (A) 和小鼠 ATF-3 转染 (B) HEK293T 全细胞裂解液中 ATF-3 表达的 Western 印迹分析.
ATF-3 抗体 (44C3a): sc-81189 对人重组 ATF-3 融合蛋白进行 Western 印迹分析.

ATF3 抗体 (44C3a): sc-81189

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说明书
  • ATF3 抗体 44C3a 是小鼠单克隆 IgG1 κ，ATF3抗体, 在28篇文献中引用，规格为100 µg/ml
  • 针对与human起源的ATF-3的内部区域对应的重组蛋白
  • 推荐用于 human 和 rat 来源的ATF-3 WB, IP, IF 和 IHC(P)检测
  • 关于如何获取ATF3 (44C3a): sc-81189的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 ATF3 抗体 (44C3a) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与ATF3 抗体 (44C3a) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 ATF 抗体包括 ATF-1, ATF-2, ATF-3, ATF-5, ATF-6 α, ATF-5 β 和 ATF-7IP

ATF-3抗体（44C3a）是一种IgG1 κ小鼠单克隆ATF-3抗体（也称为ATF3抗体或激活转录因子3抗体），可通过WB、IP、IF和IHC(P)检测人和大鼠的ATF-3蛋白。ATF-3抗体（44C3a）以非偶联抗ATF-3抗体形式提供。真核基因转录受序列特异性转录因子的调节，这些转录因子与模块化的顺式作用启动子和增强子元件结合。cAMP反应元件（CRE）是此类元件中研究得最为透彻的一种，由回文八核苷酸TGACGTCA组成。在ATF/CREB家族中已鉴定出几种CRE结合蛋白，其中研究得最为透彻的包括CREB-1、CREB-2（也称为ATF-4）、ATF-1、ATF-2和ATF-3。这些蛋白共享高度相关的COOH末端亮氨酸拉链二聚化和基本DNA结合域，但在其氨基末端域中存在高度差异。尽管ATF/CREB蛋白中的每一种似乎都能以其同源二聚体形式结合CRE，但其中的某些蛋白也以异源二聚体形式结合，既在ATF/CREB家族内，甚至也与AP-1转录因子家族的成员结合。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

ATF3 抗体 (44C3a) 参考文献:

  1. 人 CREB-2 的分子克隆：一种 ATF/CREB 转录因子，可负向调节 cAMP 反应元件的转录。  |  Karpinski, BA., et al. 1992. Proc Natl Acad Sci U S A. 89: 4820-4. PMID: 1534408
  2. 骆驼乳清蛋白通过抑制激活转录因子-3（ATF-3）介导的氧化应激并增强AKT和IκB-α的磷酸化，保护B和T细胞免于凋亡。  |  Seijffers, R., et al. 2006. Mol Cell Neurosci. 32: 143-54. PMID: 16713293
  3. 转录因子 Fos/Jun 和 ATF/CREB 的跨家族二聚化改变了 DNA 结合的特异性。  |  Hai, T. and Curran, T. 1991. Proc Natl Acad Sci U S A. 88: 3720-4. PMID: 1827203
  4. 转录因子ATF-3促进神经突起的生长。  |  Nascimento, D., et al. 2011. Neurosignals. 19: 210-21. PMID: 21912089
  5. 人类环 AMP 反应元件结合蛋白的 cDNA，该蛋白与 CREB 不同，主要在大脑中表达。  |  Kara, CJ., et al. 1990. Mol Cell Biol. 10: 1347-57. PMID: 2320002
  6. 糖尿病BB大鼠坐骨神经修复后，施万细胞和轴突生长中的激活转录因子3（ATF 3）和半胱天冬酶3的表达。  |  Feng, J., et al. 2013. Int J Clin Exp Pathol. 6: 2064-70. PMID: 24133584
  7. 二甲双胍通过诱导活化转录因子-3（ATF-3）抑制脂多糖（LPS）诱导的小鼠巨噬细胞炎症反应。  |  Kim, J., et al. 2014. J Biol Chem. 289: 23246-23255. PMID: 24973221
  8. 转录因子 ATF cDNA 克隆：能够选择性地形成 DNA 结合异二聚体的大量亮氨酸拉链蛋白家族。  |  Hai, TW., et al. 1989. Genes Dev. 3: 2083-90. PMID: 2516827
  9. 一种常见的细胞转录因子 ATF 与 E1a 和环 AMP 诱导的启动子中的调控元件相互作用。  |  Lin, YS. and Green, MR. 1988. Proc Natl Acad Sci U S A. 85: 3396-400. PMID: 2835770
  10. 鉴定大鼠体生长抑素基因中的环-AMP 反应元件。  |  Montminy, MR., et al. 1986. Proc Natl Acad Sci U S A. 83: 6682-6. PMID: 2875459
  11. 环磷酸腺苷反应性 DNA 结合蛋白：基于克隆胎盘 cDNA 的结构。  |  Hoeffler, JP., et al. 1988. Science. 242: 1430-3. PMID: 2974179
  12. ATF-3上调与喉癌的预后和增殖相关，通过调节Cyclin D1表达。  |  Zu, T., et al. 2021. Lab Invest. 101: 636-647. PMID: 33299127

订购信息

产品名称产品编号规格价格数量收藏夹

ATF3 抗体 (44C3a)

sc-81189
100 µg/ml
$333.00

ATF3 (44C3a): m-IgG Fc BP-HRP 套装

sc-539600
100 µg Ab; 10 µg BP
$354.00

ATF3 (44C3a): m-IgG1 BP-HRP 套装

sc-541588
100 µg Ab; 20 µg BP
$354.00

If I need to use anti-ATF3 in mouse tissue origin, which antibody should I order? Actually, I would like to use ATF3 (H-19) or (C-19) but it has been discontinued and replaced by ATF-3 (44C3a). However, 44C3a is not suitable for mouse tissue.

Asked by: Anonymous
Thank you for your question. ATF-3 Antibody (A-8): sc-518032 is recommended for detection of ATF-3 of mouse, rat and human origin by WB, IP, IF and ELISA.
Answered by: Tech Support Europe
Date published: 2024-05-23

Hi, I would like to request a free sample of the ATF-3 antibody (44C3a, sc-81189). Best, Floris

Asked by: Floris Leenders
Thank you for your question. Please contact Technical Service for information on how to obtain a sample.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-14

This antibody can be used for mouse tissue?

Asked by: ttta
Thank you for the question. THis clone is recommended for detection of ATF-3 of human and rat origin by WB, IP, IF and IHC(P). We do not recommend this antibody for tissue samples of mouse origin.
Answered by: Technical Support Europe
Date published: 2017-12-27

I need to use an antibody to detect the protein in samples of porcine origin. Do you know if this mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 9
Date published: 2017-01-24
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Rated 3 out of 5 by from good featureI used the antibody in 1:200 dilution and the band is very clear in MCF7 cells
Date published: 2018-04-12
Rated 4 out of 5 by from Detects a band between 22-25 kDaTested free sample. Gives a band at 22-25kDa (Not as in the picture associated with the product), minimal background
Date published: 2018-01-23
Rated 5 out of 5 by from Good choice for ATF-3ATF-3 Antibody (44C3a) is suitable for human and rat and featured in publications used in both WB and IF applications.
Date published: 2017-01-05
Rated 4 out of 5 by from Great results in WB using 1:500 dilutionGreat results in WB using 1:500 dilution on 25 g total protein lysate (rabbit embryo). -SCBT Publication Review
Date published: 2015-04-19
Rated 4 out of 5 by from WB: clearWB: clear, singular band when tested on human recombinant ATF-3 fusion protein. -SCBT QC
Date published: 2013-10-22
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ATF3 抗体 (44C3a) is rated 4.0 out of 5 by 5.
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