Date published: 2025-9-6
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ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 Antibody (8D7) - Western Blotting - Image 387695
使用 ASGPR1 抗体 (8D7) Alexa Fluor® 680: sc-52623 AF680 检测人肝脏组织提取物中 ASGPR1 的表达, 使用 GAPDH (G-9) Alexa Fluor® 790: sc-365062 AF790 检测人肝脏组织提取物中 GAPDH 的表达. 用 UltraCruz® 阻断试剂: sc-516214 阻断.
ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 Antibody (8D7) - Western Blotting - Image 387695
使用 ASGPR1 抗体 (8D7) Alexa Fluor® 680: sc-52623 AF680 检测人肝脏组织提取物中 ASGPR1 的表达, 使用 GAPDH (G-9) Alexa Fluor® 790: sc-365062 AF790 检测人肝脏组织提取物中 GAPDH 的表达. 用 UltraCruz® 阻断试剂: sc-516214 阻断.
ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 Antibody (8D7) - Flow Cytometry - Image 14457
ASGPR1 抗体 (8D7): sc-52623. 用 ASGPR1 抗体 (8D7) 染色的 Hep G2 细胞的间接 FCM 分析, 然后用 PE 结合的山羊抗小鼠 IgG: sc-3738. 黑线直方图代表同型对照, 正常小鼠 IgG1: sc-3877.
ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 Antibody (8D7) - Western Blotting - Image 391014
ASGPR1 抗体 (8D7) Alexa Fluor® 790: sc-52623 AF790. 直接近红外 Western 印迹分析人肝脏组织提取物中 ASGPR1 的表达. 用 UltraCruz® 阻断试剂阻断: sc-516214.
使用 ASGPR1 抗体 (8D7) Alexa Fluor® 680: sc-52623 AF680 检测人肝脏组织提取物中 ASGPR1 的表达, 使用 GAPDH (G-9) Alexa Fluor® 790: sc-365062 AF790 检测人肝脏组织提取物中 GAPDH 的表达. 用 UltraCruz® 阻断试剂: sc-516214 阻断.

ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 抗体 (8D7): sc-52623

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说明书
  • ASGPR1/Asialoglycoprotein Receptor 1/ASGR1抗体(8D7)是小鼠单克隆IgG1 κ, 在15篇文献中引用，规格为200 µg/ml
  • 对rat来源的肝质膜提取物
  • 抗-ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 抗体 (8D7) 推荐用于 WB, IP, IF 和 FCM，检测mouse, rat 和human 来源的 ASGPR1
  • 抗ASGPR1/Asialoglycoprotein Receptor 1/ASGR1抗体（8D7）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 另提供生物素偶联抗体，可用于WB、IHC(P)和ELISA实验
  • 关于如何获取ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 (8D7): sc-52623的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP和 1 BP-HRP">m-IgG1 BP-HRP是ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 Antibody (8D7) for WB applications. 的首选辅助检测试剂，这些试剂现与ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 Antibody (8D7) 打包提供（请参阅下面的订购信息）。

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描述
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说明书与实验方案
研究信息

関連項目

额外ASGPR抗体，包括ASGPR2

ASGPR1 抗体 (8D7) 是一种小鼠单克隆 IgG1 kappa 轻链抗体，可通过免疫印迹 (WB)、免疫沉淀 (IP)、免疫荧光 (IF) 和流式细胞仪 (FCM) 等应用检测小鼠、大鼠和人样本中的 ASGPR1。ASGPR1 (8D7) 抗体有非共轭型和多种共轭型，包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 共轭物。Asialoglycoprotein Receptor (ASGPR) 又称肝凝集素，是一种主要在肝细胞中表达的 II 型整体膜蛋白，ASGPR 在糖蛋白从血液循环中清除的过程中起着至关重要的作用。ASGPR1 由两个同源亚基 ASGPR1 和 ASGPR2 组成，它们形成多聚体复合物，包含四个功能域：胞浆结构域、跨膜结构域、柄结构域和碳水化合物识别结构域（CRD）。CRD 使 ASGPR 能够在钙存在的情况下特异性地结合具有末端半乳糖和 N-乙酰半乳糖胺残基的糖蛋白，从而促进 ASGPR-糖蛋白复合物内化到细胞中。内化后，受体和配体解离，使 ASGPR 重新回到细胞膜。ASGPR 可与乙型肝炎病毒（HBV）相互作用，介导 HBV 进入肝细胞，这突显了 ASGPR 作为 HBV 感染治疗靶点的潜力。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 抗体 (8D7) 参考文献:

  1. 拟糖蛋白受体 H1 亚基碳水化合物识别域的晶体结构。  |  Meier, M., et al. 2000. J Mol Biol. 300: 857-65. PMID: 10891274
  2. 用一种新型单克隆抗体检测肝细胞和肝外细胞表面asialoglycoprotein受体的表达。  |  Park, JH., et al. 2006. Biotechnol Lett. 28: 1061-9. PMID: 16799763
  3. [优化表达抗人异糖蛋白受体的单链 Fv 抗体并确定其亲和力常数]。  |  Wang, WY., et al. 2006. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 22: 504-6. PMID: 16806017
  4. 通过肝脏asialoglycoprotein受体全身输送Apoptin基因抑制肝癌。  |  Peng, DJ., et al. 2007. Cancer Gene Ther. 14: 66-73. PMID: 16874360
  5. 通过糖蛋白受体介导的肝细胞靶向--策略与应用。  |  D'Souza, AA. and Devarajan, PV. 2015. J Control Release. 203: 126-39. PMID: 25701309
  6. 自身免疫性肝病患者对糖蛋白受体（ASGPR）的自身抗体。  |  Villalta, D., et al. 2015. Clin Chim Acta. 450: 1-5. PMID: 26220739
  7. LYTACs 可与asialoglycoprotein 受体结合，实现有针对性的蛋白质降解。  |  Ahn, G., et al. 2021. Nat Chem Biol. 17: 937-946. PMID: 33767387
  8. 人同种糖蛋白受体的高产率纯化和特征描述。  |  Treichel, U., et al. 1995. Protein Expr Purif. 6: 251-5. PMID: 7663158
  9. 在缺乏次要受体亚基的小鼠体内，肝细胞表面会表达asialoglycoprotein受体的主要亚基。  |  Braun, JR., et al. 1996. J Biol Chem. 271: 21160-6. PMID: 8702886
  10. 受体介导的乙型肝炎病毒颗粒进入肝细胞。  |  Treichel, U., et al. 1997. Arch Virol. 142: 493-8. PMID: 9349295
  11. 在肝外细胞系中检测asialoglycoprotein受体。  |  Park, JH., et al. 1998. Biochem Biophys Res Commun. 244: 304-11. PMID: 9514919
  12. 对含有多柔比星和半乳糖胺的 HPMA 共聚物分布情况的初步临床研究。  |  Julyan, PJ., et al. 1999. J Control Release. 57: 281-90. PMID: 9895415

订购信息

产品名称产品编号规格价格数量收藏夹

ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 抗体 (8D7)

sc-52623
200 µg/ml
$316.00

ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 (8D7): m-IgG Fc BP-HRP 套装

sc-526756
200 µg Ab; 10 µg BP
$354.00

ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 (8D7): m-IgG1 BP-HRP 套装

sc-532129
200 µg Ab; 20 µg BP
$354.00

ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 抗体 (8D7) AC

sc-52623 AC
500 µg/ml, 25% agarose
$416.00

ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 抗体 (8D7) HRP

sc-52623 HRP
200 µg/ml
$316.00

ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 抗体 (8D7) FITC

sc-52623 FITC
200 µg/ml
$330.00

ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 抗体 (8D7) PE

sc-52623 PE
200 µg/ml
$343.00

ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 抗体 (8D7) Alexa Fluor® 488

sc-52623 AF488
200 µg/ml
$357.00

ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 抗体 (8D7) Alexa Fluor® 546

sc-52623 AF546
200 µg/ml
$357.00

ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 抗体 (8D7) Alexa Fluor® 594

sc-52623 AF594
200 µg/ml
$357.00

ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 抗体 (8D7) Alexa Fluor® 647

sc-52623 AF647
200 µg/ml
$357.00

ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 抗体 (8D7) Alexa Fluor® 680

sc-52623 AF680
200 µg/ml
$357.00

ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 抗体 (8D7) Alexa Fluor® 790

sc-52623 AF790
200 µg/ml
$357.00

ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 抗体 (8D7) B

sc-52623 B
200 µg/ml
$320.00

Does this antibody recognize the extracellular domain of ASGPR1 protein?

Asked by: Duc Cornell
Thank you for your question. ASGPR1 is found in the intracellular domain. https://www.uniprot.org/uniprotkb/P02706/entry#expression
Answered by: BlakeJ
Date published: 2024-09-03

Do you know if sc-52623 will react with my zebrafish samples?

Asked by: Cweed
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 8
Date published: 2017-01-20
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Rated 4 out of 5 by from buon anticorpoHo testato anticorpo per immunofluorescenza su epatociti derivati da iPSC. Segnale buono e specifico. Usato 1:500
Date published: 2022-01-14
Rated 4 out of 5 by from Test on bovine samplesThe product has been tested in western blot against samples derived from bovine plasma and bovine liver extract. Tests were run at 1:1000 and 1:500 dilutions in PBS + 0.05% tween-20 + 1% fat-free milk. As stated in the datasheet, the antibody should detect a band around 46 kDa in mouse, rat and human samples. The reactivity on bovine samples has never been tested. In our experiments, we detected a band between 37 kDa and 25 kDa. It is worth to notice that the same antibody purchased by another company gave us similar results. Moreover, the molecular weight of the protein has been predicted to be around 33 kDa in human, rat, mouse and bovine. We could detect a strong clear signal in bovine liver extract; a fainter but clear band was also present in samples derived from bovine plasma. The antibody has also been tested for immunoprecipitation of bovine plasma samples. In this case, ASGR1 detection in western blot was performed using a polyclonal rabbit antibody. The same band between 37 kDa and 25 kDa was detected.
Date published: 2020-02-04
Rated 4 out of 5 by from 特異的なバンドデータシートと同様の位置にクリアなバンドを確認することができて満足しています。特異性も十分だと思います。
Date published: 2019-08-09
Rated 1 out of 5 by from Not work on mouse tissueI tried it on mouse liver tissue section, there is no signal, maybe it cant regconize mouse Asgpr1
Date published: 2018-02-05
Rated 5 out of 5 by from Great FCM dataVery nice FCM results; need to see other applications
Date published: 2017-02-03
Rated 5 out of 5 by from Looking for an ASGPR1 antibody?Then this is your best choice! Specific and sensitive, a great combination for WB, IF and FCM experiments.
Date published: 2016-12-20
Rated 4 out of 5 by from Robust indirect FCM analysis of Hep G2 cellsRobust indirect FCM analysis of Hep G2 cells stained with ASGPR1 . -SCBT QC
Date published: 2015-04-25
Rated 4 out of 5 by from No commentNo comment.
Date published: 2015-03-27
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ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 抗体 (8D7) is rated 3.9 out of 5 by 8.
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