Arcyriaflavin A CAS: 118458-54-1
MF: C20H11N3O2
MW: 325.3
A potent inhibitor of CDK4/cyclin D1.

Arcyriaflavin A (CAS 118458-54-1)

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应用; A potent inhibitor of CDK4/cyclin D1
CAS号码: 118458-54-1
纯度: ≥95%
分子量: 325.3
分子式: C20H11N3O2
* 参考分析证明 大量特定数据 (包括水 含量).
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Arcyriaflavin A is a potent inhibitor of CDK4/cyclin D1 (IC50 = 59nM). It inhibits human cytomegalovirus (HCMV) replication in cell culture (IC50 = 200nM). Arcyriaflavin A is also a CaMKII inhibitor.


参考文献

1. Horton, P.A., et al. 1994. Experientia. 50: 843-845. PMID: 7925852
2. Slater, M.J., et al. 1999. Bioorg. Med. Chem. 7: 1067-1074. PMID: 10428375
3. Sanchez-Martinez, C., et al. 2003. Bioorg. Med. Chem. Lett. 13: 3835-3839. PMID: 14552791
4. Zhu, G., et al. 2003. Bioorg. Med. Chem. Lett. 13: 1231-1235. PMID: 12657252
5. Liu, R., et al. 2007. Arch. Pharm. Res. 30: 270-274. PMID: 17424930

用法 :
Stock solutions are stable for up to 3 months at -20°C. Whenever possible solutions should be made up and used on the same day.
物理状态 :
Solid
来源于 :
Synthetic. Originally isolated from the marine ascidian Eudistoma sp.
溶解度 :
Soluble in DMSO (100 mM).
保存 :
Store at -20° C
熔点 :
300.41° C (Predicted)
沸点 :
687.98° C (Predicted)
密度 :
1.62 g/cm3 (Predicted)
折射率 :
n20D 1.96 (Predicted)
IC50 :
human cytomegalovirus (HCMV) replication: IC50 = 200 nM; CaM kinase II: IC50 = 25 nM; CDK4 / cyclin D1: IC50 = 59 nM
pK值 :
pKa: 10.74 (Predicted)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
5327726
MDL 号码 :
MFCD03452662
SMILES :
CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCN(C)C

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引用1 - 22

PMID: # 28720098  Hirakawa, T. et al. 2017. Reprod. Biol. Endocrinol. 15: 53.

PMID: # 31160361  Infect. Immun. 87:

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