Arc Antibody (40): sc-136278

Arc Antibody (40) is a mouse monoclonal IgG1 antibody engineered to recognize an epitope spanning amino acids 377-396 at the C-terminus of the Arc protein, also known as activity-regulated cytoskeleton-associated protein or Arg3.1, from rat origin. Arc (40) antibody is effective for detecting Arc in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. Arc (40) monoclonal antibody recognizes a protein that plays a crucial role in synaptic plasticity, learning, and memory by regulating the actin cytoskeleton within neuronal cells. Structurally, Arc undergoes various post-translational modifications, including phosphorylation and ubiquitination, which are essential for stability, localization, and interaction with other synaptic proteins, thereby influencing synaptic strength and plasticity. Arc is predominantly localized in neuronal cell bodies and dendrites in key brain regions such as the hippocampus, amygdala, hypothalamus, striatum, and cortex, where Arc integrates neuronal activity signals to drive structural and functional synaptic changes. Arc′s interaction with actin and actin-associated proteins underscores Arc′s importance in maintaining the dynamic architecture of dendritic spines, which is vital for adaptive neural network function. Additionally, Arc expression is rapidly induced by stimuli like growth factors and neurotransmitters, enabling Arc to mediate long-term cellular responses essential for cognitive processes. Anti-Arc antibody (40) helps researchers accurately investigate post-translational modifications and functional dynamics of Arc, thereby advancing the understanding of neural plasticity and its implications in neurological disorders.

The preferred Arc antibody is Arc Antibody (C-7): sc-17839.