Date published: 2025-9-7
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apolipoprotein E/apoE Antibody (A1.4) - Western Blotting - Image 352741
载脂蛋白抗体 (A1. 4): sc-13521. Hep G2 全细胞裂解液 (A) 和人肝 (B), 人胎肝 (C) 和人肾 (D) 组织提取物中载脂蛋白表达的 Western 印迹分析.
载脂蛋白抗体 (A1. 4): sc-13521. Hep G2 全细胞裂解液 (A) 和人肝 (B), 人胎肝 (C) 和人肾 (D) 组织提取物中载脂蛋白表达的 Western 印迹分析.

apolipoprotein E/apoE 抗体 (A1.4): sc-13521

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寫評論提問

说明书
  • apolipoprotein E/apoE 抗体 A1.4 是小鼠单克隆 IgG1 κ，apolipoprotein E/apoE抗体, 在32篇文献中引用，规格为200 µg/ml
  • 免疫human物种的apoE的氨基酸126-191
  • apolipoprotein E/apoE 抗体 (A1.4) 推荐用于WB, IP, IF 和 IHC(P)，检测human 来源的 apoE
  • 抗apolipoprotein E/apoE抗体（A1.4）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取apolipoprotein E/apoE (A1.4): sc-13521的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP 和 m-IgGκ BP-HRP 是 apolipoprotein E/apoE 抗体 (A1.4) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与apolipoprotein E/apoE 抗体 (A1.4) 组合成套装提供。 (请参阅下面的订购信息)。

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相关产品
描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 Apolipoprotein 抗体 包括 apoA-I, apoA-II, apoA-IV, apoA-V, apoC-I, apoC-II, apoC-III, apoC-IV, apoL1和apoL3

apoE抗体（A1.4）是一种小鼠单克隆IgG1 kappa轻链抗体，可特异性识别载脂蛋白E（apoE）蛋白，靶向人类载脂蛋白E蛋白的氨基酸126-191。载脂蛋白E是一种参与脂质代谢的关键蛋白，可调节脂蛋白颗粒的结合、内化和降解。载脂蛋白E是低密度脂蛋白受体和肝载脂蛋白E受体的配体，在胆固醇运输和稳态中发挥着重要作用。这一功能至关重要，因为apoE失调与多种疾病有关，包括动脉粥样硬化等心血管疾病。apoE有多种同型异构体：E2、E3和E4，它们在结构上略有不同，但在功能上差异显著，其中E4与神经退行性疾病风险增加明显相关。apoE在大多数器官中产生，存在于所有血浆脂蛋白组分中，参与多种生理过程，包括脂质转运、血管生成和细胞增殖。抗apoE抗体（A1.4）推荐用于蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和石蜡包埋切片免疫组织化学（IHCP）等应用，是研究人员研究apoE相关途径的多功能工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

apolipoprotein E/apoE 抗体 (A1.4) 参考文献:

  1. 在转基因小鼠体内过量表达载脂蛋白 E：除高密度脂蛋白外，血浆脂蛋白明显减少，并能抵抗饮食诱导的高胆固醇血症。  |  Shimano, H., et al. 1992. Proc Natl Acad Sci U S A. 89: 1750-4. PMID: 1542669
  2. 载脂蛋白E、受体与阿尔茨海默病的调节。  |  Zhao, N., et al. 2018. Biol Psychiatry. 83: 347-357. PMID: 28434655
  3. 载脂蛋白E、牙周病和动脉粥样硬化的风险：综述。  |  Pereira, LC., et al. 2019. Arch Oral Biol. 98: 204-212. PMID: 30503976
  4. 针对阿尔茨海默病的载脂蛋白E：行业视角。  |  Suidan, GL. and Ramaswamy, G. 2019. Int J Mol Sci. 20: PMID: 31052389
  5. 载脂蛋白E对哺乳动物卵巢类固醇生成和人类生育能力的影响。  |  Oriá, RB., et al. 2020. Trends Endocrinol Metab. 31: 872-883. PMID: 32684408
  6. 载脂蛋白 E：胆固醇转运蛋白，在细胞生物学中的作用不断扩大。  |  Mahley, RW. 1988. Science. 240: 622-30. PMID: 3283935
  7. 载脂蛋白E在心脏代谢和神经健康与疾病中的作用。  |  Alagarsamy, J., et al. 2022. Int J Mol Sci. 23: PMID: 36077289
  8. 脂蛋白E在脂质代谢和神经退行性疾病中的作用。  |  Yang, LG., et al. 2023. Trends Endocrinol Metab. 34: 430-445. PMID: 37357100
  9. 载脂蛋白 E 的遗传异质性及其对血浆脂质和脂蛋白水平的影响。  |  de Knijff, P., et al. 1994. Hum Mutat. 4: 178-94. PMID: 7833947
  10. 载脂蛋白 E：内皮细胞和肿瘤细胞增殖的有效抑制剂。  |  Vogel, T., et al. 1994. J Cell Biochem. 54: 299-308. PMID: 8200910
  11. 正常脂血症患者餐后脂蛋白的清除：载脂蛋白 E 表型的作用。  |  Orth, M., et al. 1996. Biochim Biophys Acta. 1303: 22-30. PMID: 8816849
  12. 雌激素通过雌激素受体α介导的途径增加翻译池中的载脂蛋白 E（ApoE）mRNA，从而上调载脂蛋白 E（ApoE）基因的表达。  |  Srivastava, RA., et al. 1997. J Biol Chem. 272: 33360-6. PMID: 9407129

订购信息

产品名称产品编号规格价格数量收藏夹

apolipoprotein E/apoE 抗体 (A1.4)

sc-13521
200 µg/ml
$316.00

apolipoprotein E/apoE (A1.4): m-IgG Fc BP-HRP 套装

sc-528284
200 µg Ab; 10 µg BP
$354.00

apolipoprotein E/apoE (A1.4): m-IgGκ BP-HRP 套装

sc-520623
200 µg Ab, 40 µg BP
$354.00

apolipoprotein E/apoE (A1.4): m-IgG1 BP-HRP 套装

sc-542852
200 µg Ab; 20 µg BP
$354.00

apolipoprotein E/apoE 抗体 (A1.4) AC

sc-13521 AC
500 µg/ml, 25% agarose
$416.00

apolipoprotein E/apoE 抗体 (A1.4) HRP

sc-13521 HRP
200 µg/ml
$316.00

apolipoprotein E/apoE 抗体 (A1.4) FITC

sc-13521 FITC
200 µg/ml
$330.00

apolipoprotein E/apoE 抗体 (A1.4) PE

sc-13521 PE
200 µg/ml
$343.00

apolipoprotein E/apoE 抗体 (A1.4) Alexa Fluor® 488

sc-13521 AF488
200 µg/ml
$357.00

apolipoprotein E/apoE 抗体 (A1.4) Alexa Fluor® 546

sc-13521 AF546
200 µg/ml
$357.00

apolipoprotein E/apoE 抗体 (A1.4) Alexa Fluor® 594

sc-13521 AF594
200 µg/ml
$357.00

apolipoprotein E/apoE 抗体 (A1.4) Alexa Fluor® 647

sc-13521 AF647
200 µg/ml
$357.00

apolipoprotein E/apoE 抗体 (A1.4) Alexa Fluor® 680

sc-13521 AF680
200 µg/ml
$357.00

apolipoprotein E/apoE 抗体 (A1.4) Alexa Fluor® 790

sc-13521 AF790
200 µg/ml
$357.00

I have run out of my usual goat anti-mouse secondary antibody. What do you recommend I use for detection in my WB?

Asked by: cjMara
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 10
Date published: 2017-01-13

Can I use apoE Antibody (A1.4): sc-13521 for detection in mouse samples?

Asked by: cjMara
We have not yet validated this antibody for use in mouse samples, it is only currently validated for use in human. We would recommend one of our alternative clones, sc-390925: apoE (F-9) which is recommended for use in mouse.
Answered by: Technical Support 10
Date published: 2017-01-13
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Rated 1 out of 5 by from Does not work for FCMThe apoE antibody does not work for FCM with HFF cells.
Date published: 2018-11-15
Rated 4 out of 5 by from Great antibody for plasmaI tried this antibody for mouse and human plasma sample. Works great !
Date published: 2018-03-06
Rated 4 out of 5 by from Good productThe result shows positive signal in A549 whole cell lysates. Works very well in WB at 1:500 dilution, satisfied result.
Date published: 2017-05-17
Rated 5 out of 5 by from Wow !! OutstandingSuperb IF and IHC staining data; also great WB results
Date published: 2017-01-23
Rated 5 out of 5 by from Good for stainingThis apoE antibody shows good results for staining.
Date published: 2017-01-14
Rated 5 out of 5 by from detect the PD biomerker(ApoE) in hyperlipidemia paI bought this antibody several months aga. It can detect the PD biomerker(ApoE) in hyperlipidemia patients. It works very specific to the target as the capture antibody in ELISA
Date published: 2016-12-17
Rated 5 out of 5 by from Good publishable data in WB in human HepG2 cellsGood publishable data in WB in human HepG2 cells. -SCBT Publication Review
Date published: 2015-04-12
Rated 5 out of 5 by from Good specificity in WB in human platelet extractGood specificity in WB in human platelet extract. -SCBT QC
Date published: 2015-03-04
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apolipoprotein E/apoE 抗体 (A1.4) is rated 4.5 out of 5 by 11.
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