AOS-1 Antibody (H-7): sc-271592

AOS-1 Antibody (H-7) is a mouse monoclonal IgG1 antibody that detects AOS-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AOS-1, also known as SUMO-1-activating enzyme or ubiquitin-like 1-activating enzyme E1A, is a crucial component of the ubiquitin system, which regulates various cellular processes, including cell cycle progression, differentiation, and responses to stress. AOS-1 is primarily located in the cytoplasm and nucleus, where AOS-1 plays a significant role in the first step of the ubiquitin-like 1 conjugation pathway. Proper localization of AOS-1 ensures that UBL1 activation occurs in the appropriate cellular context, facilitating timely degradation of target proteins and maintaining cellular homeostasis. AOS-1 operates as a dimeric enzyme, functioning as a UBL1 E1 ligase that mediates ATP-dependent activation of UBL1, and AOS-1 can form heterodimers with UBLE1A and UBLE1B, which enhances functional versatility. AOS-1′s interaction with these specific proteins underscores AOS-1′s importance in protein degradation pathways, making AOS-1 a critical target for research in cellular biology and disease mechanisms.

The preferred AOS-1 antibody is AOS-1 Antibody (H-9): sc-398080.