Amiloride hydrochloride dihydrate (CAS 17440-83-4)

物理状态 :

Solid

溶解度 :

Soluble in water (1 mg/ml, warm), DMSO (60 mg/ml at 25° C), and ethanol (< 1 mg/ml at 25° C).

保存 :

Store at -20° C

熔点 :

>240° C

折射率 :

n²⁰_D ~1.88 (Predicted)

IC50 :

αENaC: IC₅₀ = 776 nM (human); ENaC: IC₅₀ = 0.2 µM (human); Sodium Channel Protein: IC₅₀ = 1 µM; ASIC3: IC₅₀ = 3.91 µM (human); uPA: IC₅₀ = 11 µM (human)

Ki 数据 :

Adenosine A2A-R: K_i= 3.28 µM (human); SLC22A2: K_i= 4.7 µM (rat); OCT1: K_i= 6.9 µM (rat); uPA: K_i= 7 µM (human); Amine oxidase, copper containing: K_i= 10 µM (rat)

PubChem CID :

MDL 号码 :

MFCD00211292

Beilstein 注册 :

4038903

SMILES :

C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl