Amantadine-d15 Hydrochloride CAS: 665-66-7 (unlabeled)
MF: C10H3D15ClN
MW: 202.80
An antagonist of the NMDA receptor.

Amantadine-d15 Hydrochloride (CAS 665-66-7 (unlabeled))

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应用; An antagonist of the NMDA receptor
CAS号码: 665-66-7 (unlabeled)
纯度: 98%
分子量: 202.80
分子式: C10H3D15ClN
* 参考分析证明 大量特定数据 (包括水 含量).
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Amantadine-d15 Hydrochloride is a labeled NMDA-receptor antagonist which functions by accelerating channel closure. Structurally Amantadine is composed of four methyne positions, with one position substituted with an amino group. Amantadine-d15 Hydrochloride effects antiviral strains, via interfering with the viral protein M2, an ion channel. M2 is essential for activity of the virus once it enters the cell by endocytosis. Studies indicate that Amantadine-d15 Hydrochloride functions through various mechanisms and shows no dominant mechanism of action. In addition, Amantadine-d15 Hydrochloride blocks monoaminoxidase A and raises β-endorphin/β-lipotropin levels.


参考文献

1. Maugh, T.H. 1976. Science. 192: 130-131. PMID: 17792438
2. Wang, C., et al. 1993. J. Virol. 67: 5585-5594. PMID: 7688826
3. Jing, X., et al. 2008. Proc. Natl. Acad. Sci. U.S.A. 105: 10967-10972. PMID: 18669647

物理状态 :
Solid
溶解度 :
Solubility: Soluble in Alcohol, Chloroform and Water
保存 :
Store at -20° C
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
45038100
SMILES :
[2H]C1([2H])C2([2H])C([2H])([2H])C3([2H])C([2H])([2H])C1([2H])C([2H])([2H])C(N)(C2([2H])[2H])C3([2H])[2H]

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