ALPPL2 抗体 (9-YD35): sc-134255

ALPPL2 Antibody (9-YD35) is an IgG_2a κ mouse monoclonal ALPPL2 antibody (also designated ALPG antibody, ALPPL antibody, or GCAP antibody) suitable for the detection of the ALPPL2 protein of human origin by WB, IP, IF, IHC(P) and ELISA. ALPPL2 Antibody (9-YD35) is available as the non-conjugated anti-ALPPL2 antibody. ALPPL2 (alkaline phosphatase, placental-like 2), also known as ALPG, GCAP or ALPPL, is a 532 amino acid protein that is lipid-anchored to the cell membrane and belongs to the alkaline phosphatase family. Expressed at low levels in thymus and testis, ALPPL2 functions as a homodimer that uses magnesium and zinc as cofactors to catalyze the conversion of a phosphate monoester to an alcohol and a free phosphate. ALPPL2 is overexpressed in germ cell tumors, suggesting a role in tumor development and progression. The gene encoding ALPPL2 maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, Alström syndrome, is caused by mutations in the ALMS1 gene, which maps to chromosome 2.

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References:

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4. Characterization of the placental alkaline phosphatase-like (Nagao) isozyme on the surface of A431 human epidermoid carcinoma cells.  |  Jemmerson, R., et al. 1985. Cancer Res. 45: 282-7. PMID: 2578098
5. 5′ nucleotide sequence of a putative human placental alkaline phosphatase-like gene.  |  Shen, LP., et al. 1988. Nucleic Acids Res. 16: 5694. PMID: 3387245
6. Molecular cloning and sequence analysis of human placental alkaline phosphatase.  |  Millán, JL. 1986. J Biol Chem. 261: 3112-5. PMID: 3512548
7. The human placental alkaline phosphatase gene and related sequences map to chromosome 2 band q37.  |  Martin, D., et al. 1987. Ann Hum Genet. 51: 145-52. PMID: 3674755
8. A possible new locus of alkaline phosphatase expressed in human testis.  |  Millán, JL., et al. 1982. Hum Genet. 62: 293-5. PMID: 7166303